Intramural Blood Flow and Blood Volume in the Small Intestine of the Gat as Analyzed by an Indicator-Dilution Technique

Intrarenal blood flow and volume (indicator-dilution technique), kidney volume (mercury-in-rubber resistance gage), intr-renal venous pressure, filtration fraction, and sodium excretion were determined dequentially before and during a l-h infusion of isotonicsaline 80 ml/kg in anesthetized dogs. The cortical fraction of renal blood flow roseduring the first 20 min of infusion from an average of 70 to 77%, butreturned nearly to control levels during the last 20 min of infusion because ofa low rise in noncortical flow. During the first 20 min a 23% increase in cortical blood volume accounted for one-third of the 8.5% increase in kidney volume, whereasin the last 20 min cortical blood volume had fallen nearly to control values and kidneyvolume was increased by 17.2%. Intrarenal resistances calculated from intrarenalpressure and flow indicated persistent cortical prevenous dilatation, progressive cortical venous constriction, and only a slight late reduction in noncortical resistance.These data indicate that hemodynamics are shanging continuously during saline infusion and the natriuresis probably is multifactorial.

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Determination of Leg Blood Flow During Exercise in Man: An Indicator-Dilution Technique Based on Femoral Venous Dye Infusion

Clinical Science ◽

10.1042/cs0450135 ◽

1973 ◽

Vol 45 (2) ◽

pp. 135-146 ◽

Cited By ~ 5

Author(s):

J. Wahren ◽

L. Jorfeldt

Keyword(s):

Blood Flow ◽

Healthy Subjects ◽

Femoral Vein ◽

Indicator Dilution ◽

Dilution Method ◽

Dilution Technique ◽

Flow Measurements ◽

Leg Blood Flow ◽

Indicator Dilution Technique

1. A dye-dilution method has been developed for the determination of leg blood flow in man. The method is based on the infusion of indicator into the distal part of the femoral vein with blood sampling from the same vein at the level of the inguinal ligament. Catheterization of the femoral artery is not required. Evidence of adequate mixing of dye and blood is presented, based on the finding of the same dye concentration in samples from two different levels in the femoral vein. 2. Leg blood flow measured by this technique at rest and during exercise in six healthy subjects was found to agree closely with simultaneous determinations with an intra-arterial indicator-dilution technique. The reproducibility of the blood-flow measurements, expressed as the coefficient of variation for a single determination, was 9·8%. 3. A routine procedure is suggested for leg blood-flow determination based on femoral venous dye infusion. Using this procedure, leg blood flow was measured in twelve healthy subjects at rest and during exercise at work loads of 100, 200, 400 and 600 kpm/min. A linear relationship was found between leg blood flow and pulmonary oxygen uptake. 4. The applicability of this method to the study of patients with occlusive arterial disease of the leg is illustrated by findings in two patients before and after vascular reconstruction.

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Bedside Assessment of Cerebral Blood Flow by Double-indicator Dilution Technique

Anesthesiology ◽

10.1097/00000542-200002000-00017 ◽

2000 ◽

Vol 92 (2) ◽

pp. 367-367 ◽

Cited By ~ 27

Author(s):

Götz J. K. Wietasch ◽

Frank Mielck ◽

Martin Scholz ◽

Tilman von Spiegel ◽

Heidrun Stephan ◽

...

Keyword(s):

Blood Flow ◽

Cerebral Blood Flow ◽

Clinical Setting ◽

Coronary Bypass ◽

Central Venous Line ◽

Indicator Dilution ◽

Alternative Methods ◽

Dilution Technique ◽

Indicator Dilution Technique ◽

Double Indicator Dilution

Background Currently, quantitative measurement of global cerebral blood flow (CBF) at bedside is not widely performed. The aim of the present study was to evaluate a newly developed method for bedside measurement of CBF based on thermodilution in a clinical setting. Methods The investigation was performed in 14 anesthetized patients before coronary bypass surgery. CBF was altered by hypocapnia, normocapnia, and hypercapnia. CBF was measured simultaneously by the Kety-Schmidt inert-gas technique with argon and a newly developed transcerebral double-indicator dilution technique (TCID). For TCID, bolus injections of ice-cold indocyanine green were performed via a central venous line, and the resulting thermo-dye dilution curves were recorded simultaneously in the aorta and the jugular bulb using combined fiberoptic thermistor catheters. CBF was calculated from the mean transit times of the indicators through the brain. Results Both methods of measurement of CBF indicate a decrease during hypocapnia and an increase during hypercapnia, whereas cerebral metabolic rate remained unchanged. Bias between CBF(TCID) and CBFargon was -7.1+/-2.2 (SEM) ml x min(-1) x 100 g(-1); precision (+/- 2 x SD of differences) between methods was 26.6 ml x min(-1) x 100 g(-1). Conclusions In the clinical setting, TCID was feasible and less time-consuming than alternative methods. The authors conclude that TCID is an alternative method to measure global CBF at bedside and offers a new opportunity to monitor cerebral perfusion of patients.

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