The contribution of systems biology and reverse genetics to the understanding of Kaposi’s sarcoma-associated herpesvirus pathogenesis in endothelial cells
2009 ◽
Vol 102
(12)
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pp. 1117-1134
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Keyword(s):
SummaryKaposi’s sarcoma-associated herpesvirus (KSHV) / human herpesvirus-8 is the causative agent of the endothelial cell-derived tumour Kaposi’s sarcoma. Herpesviruses possess large complex genomes which provide many options to regulate cellular physiology during the viral life cycle and in the course of tumourigenicity. Novel techniques of systems biology and reverse genetics are increasingly applied to dissect the complex interaction of KSHV with endothelial cells. This review will outline novel results and pitfalls of these technologies in the elucidation of KSHV pathogenicity.
2019 ◽
Vol 62
(8)
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pp. 3924-3939
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2003 ◽
Vol 17
(4)
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pp. 461-464
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2000 ◽
Vol 343
(19)
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pp. 1411-1413
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1998 ◽
Vol 20
(1)
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pp. 7-11
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2004 ◽
Vol 42
(7)
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pp. 3313-3316
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1997 ◽
Vol 182
(3)
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pp. 262-265
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