scholarly journals Regulation of the expression and function of TRPCs and Orai1 by Homer2 in mouse pancreatic acinar cells

2021 ◽  
Vol 46 (3) ◽  
pp. 134-139
Author(s):  
Jung Yun Kang ◽  
◽  
Namju Kang ◽  
Yu-Mi Yang
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
And Function

Visualization of CCK-evoked exocytic events in rat pancreatic acinar cells

2001 ◽  
Vol 120 (5) ◽  
pp. A24-A24
Author(s):  
H GAISANO ◽  
L TANG ◽  
L SHEU ◽  
W TRIMBLE
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells

Effects of oncogenic K-ras on pancreatic acinar cells In vitro

2001 ◽  
Vol 120 (5) ◽  
pp. A722-A722
Author(s):  
Y BI ◽  
C LOGSDON
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells

Carbon tetrachloride induced ultrastructural alterations in pancreatic acinar cells and in the hepatocytes. Similarities and differences

Toxicology ◽  
1978 ◽  
Vol 11 ◽  
pp. 289-296 ◽  
Author(s):  
Carmen R. De Castro ◽  
Adriana S. Bernacchi ◽  
Elida C. De Ferreyra ◽  
Olga M. De Fends ◽  
José A. Castro
Keyword(s):  
Carbon Tetrachloride ◽  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Ultrastructural Alterations ◽  
Similarities And Differences

scholarly journals Control of cholecystokinin receptor dephosphorylation in pancreatic acinar cells

1993 ◽  
Vol 268 (16) ◽  
pp. 12136-12142
Author(s):  
M.P. Lutz ◽  
D.I. Pinon ◽  
L.K. Gates ◽  
S. Shenolikar ◽  
L.J. Miller
Keyword(s):  
Acinar Cells ◽  
Pancreatic Acinar Cells ◽  
Cholecystokinin Receptor

scholarly journals Pancreatogenic Diabetes: Triggering Effects of Alcohol and HIV

Biology ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 108
Author(s):  
Moses New-Aaron ◽  
Murali Ganesan ◽  
Raghubendra Singh Dagur ◽  
Kusum K. Kharbanda ◽  
Larisa Y. Poluektova ◽  
...  
Keyword(s):  
Multiorgan Failure ◽  
Acinar Cells ◽  
Pancreatic Stellate Cells ◽  
Pancreatic Acinar Cells ◽  
Alcoholic Pancreatitis ◽  
People Living With Hiv ◽  
Zymogen Activation ◽  
Pancreatogenic Diabetes ◽  
Hiv Entry ◽  
Living With Hiv

Multiorgan failure may not be completely resolved among people living with HIV despite HAART use. Although the chances of organ dysfunction may be relatively low, alcohol may potentiate HIV-induced toxic effects in the organs of alcohol-abusing, HIV-infected individuals. The pancreas is one of the most implicated organs, which is manifested as diabetes mellitus or pancreatic cancer. Both alcohol and HIV may trigger pancreatitis, but the combined effects have not been explored. The aim of this review is to explore the literature for understanding the mechanisms of HIV and alcohol-induced pancreatotoxicity. We found that while premature alcohol-inducing zymogen activation is a known trigger of alcoholic pancreatitis, HIV entry through C-C chemokine receptor type 5 (CCR5) into pancreatic acinar cells may also contribute to pancreatitis in people living with HIV (PLWH). HIV proteins induce oxidative and ER stresses, causing necrosis. Furthermore, infiltrative immune cells induce necrosis on HIV-containing acinar cells. When necrotic products interact with pancreatic stellate cells, they become activated, leading to the release of both inflammatory and profibrotic cytokines and resulting in pancreatitis. Effective therapeutic strategies should block CCR5 and ameliorate alcohol’s effects on acinar cells.

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