scholarly journals Genetics of canine subvalvular aortic stenosis (SAS)

2021 ◽  
Vol 8 (1) ◽  
Author(s):  
Eric S. Ontiveros ◽  
Joshua A. Stern
Keyword(s):  
Aortic Stenosis ◽  
Left Ventricular Outflow Tract ◽  
Heart Defects ◽  
Pressure Overload ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Disease Prevalence ◽  
Outflow Tract ◽  
Left Ventricular Outflow ◽  
Subvalvular Aortic Stenosis

Abstract Subvalvular aortic stenosis (SAS) is one of the most common congenital heart defects of dogs. The disease is characterized by obstruction of the left ventricular outflow tract, resulting in pressure overload on the left ventricle. The etiology of obstruction is a fibromuscular nodule, ridge, or ring of tissue that increases aortic outflow tract velocity. This review is focused on the prevalence, inheritance pattern, and current genetic insights of canine SAS. The prevalence of this disease was reported at 4.7 % in a large veterinary referral hospital. The mode of inheritance for this disease has also been described in breeds with a high disease prevalence such as the Bullmastiff, Bouvier des Flandres, Dogue de Bordeaux, Golden Retriever, Newfoundland, and Rottweiler. Genetic investigations seeking to identify causative mutations for SAS are lacking with only a single published variant associated with SAS in Newfoundlands.

Aortic stenosis and left ventricular outflow tract obstruction

ESC CardioMed ◽  
2018 ◽  
pp. 807-810
Author(s):  
David Anderson
Keyword(s):  
Aortic Stenosis ◽  
Left Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Outflow Tract ◽  
Ventricular Outflow Tract Obstruction ◽  
Long Term Follow Up ◽  
Balloon Valvotomy ◽  
Left Ventricular Outflow

Left ventricular outflow tract obstruction can occur at subvalvar, valvar, and supravalvar levels. Severity and progression can be evaluated by echocardiography. Aortic valve stenosis can usually be relieved by balloon valvotomy, but some patients require surgery, either with valvotomy, valve replacement, or the Ross procedure. Sub- and supravalvar aortic stenosis require surgical management. Long-term follow-up of all patients is required.

scholarly journals Subaortic stenosis and mitral dysplasia in three Black Russian Terrier puppies

2012 ◽  
Vol 50 (No. 7) ◽  
pp. 321-326
Author(s):  
J. Pikula ◽  
J. Pikulova ◽  
H. Bandouchova ◽  
P. Kohout ◽  
K. Najman ◽  
...  
Keyword(s):  
Mitral Valve ◽  
Aortic Stenosis ◽  
Left Ventricular Outflow Tract ◽  
Ventricular Outflow Tract ◽  
Left Ventricular ◽  
Outflow Tract ◽  
Subaortic Stenosis ◽  
Maximum Pressure ◽  
Mitral Insufficiency ◽  
Left Ventricular Outflow

A combined congenital heart defect of aortic stenosis and mitral dysplasia was diagnosed in three Black Russian Terrier puppies two months old. The aortic stenosis component included both fixed and dynamic obstructions. The fixed obstruction was subvalvularly located at the entrance to the left ventricular outflow tract. The dynamic obstruction was caused by the septal leaflet of the mitral valve protruding into the left ventricular outflow tract. Mitral dysplasia resulted in mitral insufficiency leading to regurgitation through the mitral valve closer to the septal side. The maximum pressure gradient across the aortic valve amounting to 103 mmHg measured in one puppy was consistent with the most severe grade of stenosis. The diagnosis was confirmed by autopsy in all three puppies that were males and originated in one litter, so genetic influences are supposed.

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