The article presents a case report of patients with multimorbid pathology – hiatal hernia with gastroesophageal reflux disease, cholecystolithiasis and umbilical hernia. Simultaneous surgery was performed in all cases – laparoscopic hiatal hernia with fundoplication, laparoscopic cholecystectomy and umbilical hernia alloplasty (in three cases – by IPOM (intraperitoneal onlay mesh) method and in one – hybrid alloplasty – open access with laparoscopic imaging). After the operation in one case there was an infiltrate of the trocar wound, in one case – hyperthermia, which were eliminated by conservative methods. The follow-up result showed no hernia recurrences and clinical manifestations of gastroesophageal reflux disease.