scholarly journals Studies on Quinolone Antibiotics. III. Synthesis and Antibacterial Activity of 5-Amino-7-(2-aminoalkoxy)-1-cyclopropyl-6-fluoro-1, 4-dihydro-4-oxoquinoline-3-carboxylic Acid and Their Derivatives

1991 ◽  
Vol 111 (7) ◽  
pp. 386-392 ◽  
Author(s):  
Toshihiko YOSHIDA ◽  
Yoichi YAMAMOTO ◽  
Noriyuki YAGI ◽  
Yoshie TAKAHASI ◽  
Shingo YASUDA ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acid ◽  
Quinolone Antibiotics

ChemInform Abstract: Synthesis and Antibacterial Activity of Novel 7-Substituted-6-fluoro-1-fluoromethyl-4-oxo-4H-[1,3]thiazeto [3,2-a]quinoline-3-carboxylic Acid Derivatives.

ChemInform ◽  
2010 ◽  
Vol 31 (21) ◽  
pp. no-no
Author(s):  
Masato Matsuoka ◽  
Jun Segawa ◽  
Isao Amimoto ◽  
Yasushi Masui ◽  
Yoshifumi Tomii ◽  
...  
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acid

Synthesis and antibacterial activity of (1-aryl-1, 2, 3-triazol-4-yl) methyl esters of morpholine-3-carboxylic acid

2014 ◽  
Vol 23 (12) ◽  
pp. 5321-5327 ◽  
Author(s):  
Sirassu Narsimha ◽  
T. Ranjith Kumar ◽  
Nukala Satheesh Kumar ◽  
Shaik Yakoob ◽  
N. Vasudeva Reddy
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acid ◽  
Methyl Esters

Synthesis and Antibacterial Activity of Some 3-Hydroxyquinolones

1992 ◽  
Vol 57 (1) ◽  
pp. 188-193 ◽  
Author(s):  
Stanislav Rádl ◽  
Magda Janichová
Keyword(s):  
Antibacterial Activity ◽  
Carboxylic Acid ◽  
Hydroxy Group ◽  
Sodium Borohydride ◽  
Selenium Dioxide ◽  
Prolonged Heating

A reductive decarboxylation of 7-chloro-1-ethyl-6-fluoro-1,4-dihydro-4-oxoquinoline-3-carboxylic acid (Id) with sodium borohydride provided the respective 1,2,3,4-tetrahydro derivative Va, which was treated with selenium dioxide to give product of dehydrogenation VIa. 3-Acetyl-1-ethyl-1,4-dihydroquinolin-4-ones VIb and VIc were oxidized with 3-chloroperoxybenzoic acid to the respective 3-hydroxyderivatives IIIa and IIIb. Compound IIIb was benzylated on a hydroxy group at position 3 to corresponding 3-benzyloxy derivative VIf which after prolonged heating with N-methylpiperazine in a sealed tube provided directly 3-hydroxy-7-(4-methyl-1-piperazinyl) derivative IIIc.

Quinolone antibiotics: Study of reactivity and impurity profile of piperazine with chloro-fluoro-quinolone carboxylic acid in aqueous medium

1996 ◽  
Vol 37 (37) ◽  
pp. 6785-6786 ◽  
Author(s):  
U.R. Kalkote ◽  
V.T. Sathe ◽  
R.K. Kharul ◽  
S.P. Chavan ◽  
T. Ravindranathan
Keyword(s):  
Carboxylic Acid ◽  
Aqueous Medium ◽  
Impurity Profile ◽  
Quinolone Antibiotics
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