Hyperbaric oxygen therapy as an adjunctive treatment for pyoderma gangrenosum: a case report

<p class="abstract">Pyoderma gangrenosum is an uncommon inflammatory dermatosis associated with chronic wounds. Diagnosis and management can be challenging to clinicians due to the relapsing nature of the disorder, atypical presentations, and exclusion of other conditions before diagnosis. Hyperbaric oxygen therapy is not a mainstay of treatment for pyoderma gangrenosum, but it is used for non-healing wounds associated with diabetes and vascular insufficiency due to its primary mechanism of tissue hyperoxia, resultant angiogenesis, and reduction of edema and inflammation. This case report presents two patients with pyoderma gangrenosum who were provided adjunctive therapy with hyperbaric oxygen with favorable outcomes.</p>

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Hyperbaric Oxygen Therapy on Pyoderma Gangrenosum: A case report

Korean Journal of Anesthesiology ◽

10.4097/kjae.1975.8.2.307 ◽

1975 ◽

Vol 8 (2) ◽

pp. 307

Author(s):

Jeong Ho Park ◽

Young II Jo ◽

Jang Ha Choi ◽

Suk Hi Lee

Keyword(s):

Case Report ◽

Hyperbaric Oxygen ◽

Pyoderma Gangrenosum ◽

Hyperbaric Oxygen Therapy ◽

Oxygen Therapy

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Healing of spongiosus-cutaneous fistula with Hyperbaric Oxygen Therapy (HBOT): a case report

Urologia Journal ◽

10.1177/0391560317750027 ◽

2018 ◽

Vol 85 (1) ◽

pp. 38-40 ◽

Cited By ~ 1

Author(s):

Pier A. Della Camera ◽

Gianmartin Cito ◽

Simone Morselli ◽

Francesco Sessa ◽

Davide Facchiano ◽

...

Keyword(s):

Case Report ◽

Hyperbaric Oxygen ◽

Hyperbaric Oxygen Therapy ◽

Gold Standard ◽

Oxygen Therapy ◽

Chronic Wounds ◽

Resonance Imaging ◽

Cutaneous Fistula ◽

Compression Phase ◽

Amoxicillin Clavulanic Acid

Introduction: We present a case of a spongiosus-cutaneous fistula in a 39-year-old man with recurrent episodes of cutaneous abscess in dorsal middle third penis (5 × 3 cm) treated with Hyperbaric Oxygen Therapy (HBOT). Case report: After emptying nodular abscess, the patient was noncompliant for further surgery. Therefore, it was suggested the association between HBOT and antibiotic therapy. HBOT is carried out in a hyperbaric room, where the internal pressure is increased (compression phase) by entering compressed air up to 283.71 kPa in about 10 minutes. Every HBOT cycle lasted 24 days in which the patient had been taking Amoxicillin/Clavulanic Acid 875 mg/125 mg 3 tabs/day and Sulfamethoxazole/Trimethoprim 160 mg/800 mg 2 tabs/day for 2 weeks. At the end of the treatment, a penile magnetic resonance imaging and an ultrasonography were executed and they evidenced a complete remission of the lesion. In the subsequent 22 months, there was no recurrence. Conclusions: Our results suggest that HBOT is an effective treatment for chronic wounds, including a spongiosus-cutaneous fistula of unknown cause, when used in combination with conventional standard therapy or further interventions. At present time, the gold standard remains surgery; nevertheless, our experience with HBOT may stimulate its use in clinical trials.

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