Abstract
Background:Chronic cough is common in obstructive sleep apnea. The aetiology of chronic cough in obstructive sleep apnea patients could be multifactorial. Several studies have reported high incidence rates of gastroesophageal reflux in obstructive sleep apnea patients, and gastroesophageal reflux may be one of causes of chronic cough in OSA patients. This study aimed to investigate the effect of continuous positive airway pressure on chronic cough in obstructive sleep apnea concomitant gastroesophageal reflux patients.Methods: Obstructive sleep apnea concomitant gastroesophageal reflux patients who also suffered chronic cough were enrolled. Patients who accepted continuous positive airway pressure as treatment group, and the patients who accepted general treatment (diet control, moderate exercise, sleeping on your side, limiting alcohol consumption and proton pump inhibitor±mosapride) as control group. Effects of different treatment modalities on chronic cough were assessed, and the correlation between chronic cough, obstructive sleep apnea and gastroesophageal reflux were performed by Pearson correlation analyses. Results: All Patients had poor sleep quality, severe daytime sleepiness, moderate-severe sleep apnea, significant weak acid reflux and moderate coughing events at the baseline. Compared with the baseline, PSQI and ESS score were improved in treatment group after 1 week’s treatment, the improvement became stronger with duration of therapy (P＜0.05). GERD-Q score, VAS score, daytime and night cough symptom score were all significantly improved in these two groups after treatment (P＜0.05), while this improvement was more pronounced in the treatment group ( P＜0.05). There were significant correlation between AHI and VAS score (r=0.612, P＜0.05), weak acid reflux and VAS score (r=0.429, P＜0.05), weak acid reflux and AHI (r=0.366, P＜0.05). Conclusion: The improvement in chronic cough and gastroesophageal reflux was due to the resolution of obstructive sleep apnea. AHI and weak acid reflux may be critical factors affecting the therapeutic effect of chronic cough in obstructive sleep apnea concomitant gastroesophageal reflux patients.
Effect of Continuous Positive Airway Pressure on Chronic Cough in Patients with Obstructive Sleep Apnea and Concomitant Gastroesophageal Reflux
