scholarly journals The Legal Highs of Novel Drugs of Abuse

2016 ◽  
Vol 02 (02) ◽  
Author(s):  
Pierluigi Pompei
2016 ◽  
Author(s):  
Matthew D Zuckerman ◽  
Kavita Babu

The term “drugs of abuse” lacks a formal medical definition. Historically, discussions of drugs of abuse focused on “street drugs”; however, the adverse effects of the nonmedical use of prescription medications, such as opiates, benzodiazepines, and therapeutic amphetamines, are increasingly seen. The purpose of this review is to aid the clinician in identifying and treating a broad representation of drugs of abuse, which may include those illicitly produced in laboratories (e.g., methamphetamine), diverted pharmaceuticals (oxycodone), and herbal products (marijuana). This review covers stimulants, hallucinogens, cannabinoids, and sedative-hypnotics. Figures show substances ranked according to weighted harm score on a normalized scale from 0 being no harm to 100 being extreme harm to self and others, a treatment algorithm for sympathomimetic toxicity, a treatment algorithm for sedative-hypnotic overdose, and a treatment algorithm for opioid overdose. Tables list commonly abused sympathomimetic agents, modern novel drugs of abuse, commonly abused sedative-hypnotic agents, commonly abused opiates, and pitfalls of the drug screen.   This review contains 4 highly rendered figures, 5 tables, and 89 references


2013 ◽  
Vol 3 (2) ◽  
pp. 123-134 ◽  
Author(s):  
Ryan Vandrey ◽  
Matthew W. Johnson ◽  
Patrick S. Johnson ◽  
Miral A. Khalil
Keyword(s):  

2016 ◽  
Author(s):  
Matthew D Zuckerman ◽  
Kavita Babu

The term “drugs of abuse” lacks a formal medical definition. Historically, discussions of drugs of abuse focused on “street drugs”; however, the adverse effects of the nonmedical use of prescription medications, such as opiates, benzodiazepines, and therapeutic amphetamines, are increasingly seen. The purpose of this review is to aid the clinician in identifying and treating a broad representation of drugs of abuse, which may include those illicitly produced in laboratories (e.g., methamphetamine), diverted pharmaceuticals (oxycodone), and herbal products (marijuana). This review covers stimulants, hallucinogens, cannabinoids, and sedative-hypnotics. Figures show substances ranked according to weighted harm score on a normalized scale from 0 being no harm to 100 being extreme harm to self and others, a treatment algorithm for sympathomimetic toxicity, a treatment algorithm for sedative-hypnotic overdose, and a treatment algorithm for opioid overdose. Tables list commonly abused sympathomimetic agents, modern novel drugs of abuse, commonly abused sedative-hypnotic agents, commonly abused opiates, and pitfalls of the drug screen.   This review contains 4 highly rendered figures, 5 tables, and 89 references


2019 ◽  
Vol 40 (2) ◽  
pp. 71-78 ◽  
Author(s):  
George Sam Wang ◽  
Christopher Hoyte
Keyword(s):  

2014 ◽  
Vol 83 (2) ◽  
pp. 101-107
Author(s):  
Kinga Mruczyk ◽  
Krzysztof Durkalec-Michalski ◽  
Jan Jeszka ◽  
Joanna Lipińska ◽  
Zbigniew Stefański

Introduction. Interest in substitute drugs of abuse, commonly called “dopalacze” [literally “after-burns”] that is “legal highs”, in Poland and abuse of such products, which could pose a significant life hazard, led to legislative action taken by the government. The decision by the Chief Sanitary Inspectorate made shops commonly called “smart shops” close down, while confiscated products were subjected to chemical analyses by national research institutes.Aim. Determination of the chemical composition and possible presence of active substances contained in tested samples of substitute drugs of abuse.Material and methods. The research material consisted of 171 samples taken for analysis at the end of 2010 from retailers in Lubuskie province. Samples of “legal highs” were tested in a specialized laboratory of the Institute of Rural Medicine, Lublin, by means of liquid chromatography with mass spectrometry (HPLC-MS).Results. Laboratory analyses of “legal high” samples showed the presence of different psychoactive substances in 136 samples, representing 80% of the tested products. The compounds included psychoactive substances – MDPV (17%), 4-EMC (10%), AM-694 (10%), JWH-203 (7%), TFMPP (6%), as well as narcotics, such as mephedrone (5% samples), Piper methysticum (5%), JWH-250 (4%), JWH-200 (5%) and Salvia divinorum (2%). Chemical analyses showed that only 35 samples contained no substances that would affect the physiological and psychological condition of the human body.Conclusions. Analyses of the chemical composition of “legal highs” showed that they contained a large group of different substances or their mixtures exhibiting psychoactive and narcotic activity that may pose a significant health and life hazard.


2016 ◽  
Author(s):  
Matthew D Zuckerman ◽  
Kavita Babu

The term “drugs of abuse” lacks a formal medical definition. Historically, discussions of drugs of abuse focused on “street drugs”; however, the adverse effects of the nonmedical use of prescription medications, such as opiates, benzodiazepines, and therapeutic amphetamines, are increasingly seen. The purpose of this review is to aid the clinician in identifying and treating a broad representation of drugs of abuse, which may include those illicitly produced in laboratories (e.g., methamphetamine), diverted pharmaceuticals (oxycodone), and herbal products (marijuana). This review covers stimulants, hallucinogens, cannabinoids, and sedative-hypnotics. Figures show substances ranked according to weighted harm score on a normalized scale from 0 being no harm to 100 being extreme harm to self and others, a treatment algorithm for sympathomimetic toxicity, a treatment algorithm for sedative-hypnotic overdose, and a treatment algorithm for opioid overdose. Tables list commonly abused sympathomimetic agents, modern novel drugs of abuse, commonly abused sedative-hypnotic agents, commonly abused opiates, and pitfalls of the drug screen.   This review contains 4 highly rendered figures, 5 tables, and 89 references


2018 ◽  
Author(s):  
Matthew D Zuckerman ◽  
Kavita Babu

The term “drugs of abuse” lacks a formal medical definition. Historically, discussions of drugs of abuse focused on “street drugs”; however, the adverse effects of the nonmedical use of prescription medications, such as opiates, benzodiazepines, and therapeutic amphetamines, are increasingly seen. The purpose of this review is to aid the clinician in identifying and treating a broad representation of drugs of abuse, which may include those illicitly produced in laboratories (e.g., methamphetamine), diverted pharmaceuticals (oxycodone), and herbal products (marijuana). This review covers stimulants, hallucinogens, cannabinoids, and sedative-hypnotics. Figures show substances ranked according to weighted harm score on a normalized scale from 0 being no harm to 100 being extreme harm to self and others, a treatment algorithm for sympathomimetic toxicity, a treatment algorithm for sedative-hypnotic overdose, and a treatment algorithm for opioid overdose. Tables list commonly abused sympathomimetic agents, modern novel drugs of abuse, commonly abused sedative-hypnotic agents, commonly abused opiates, and pitfalls of the drug screen.   This review contains 4 highly rendered figures, 5 tables, and 89 references


Author(s):  
Evan S. Herrmann ◽  
Patrick S. Johnson ◽  
Matthew W. Johnson ◽  
Ryan Vandrey
Keyword(s):  

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