scholarly journals Over-expression of keratin 8 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Keratin 8 ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified keratin 8, encoded by KRT8, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. KRT8 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of KRT8 was correlated with recurrence-free survival in patients with endometrial cancer. KRT8 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of cytoskeleton associated protein 2 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified cytoskeleton associated protein 2, encoded by CKAP2, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. CKAP2 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of CKAP2 was correlated with recurrence-free survival in white patients with high and low mutational burden. CKAP2 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of KIAA0101 (PCLAF) in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified KIAA0101, also known as the PCNA clamp-associated factor (PCLAF) as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. KIAA0101 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of KIAA0101 was correlated with recurrence-free survival in patients with endometrial cancer. KIAA0101 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of nucleolar and spindle associated protein 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified nucleolar and spindle associated protein 1, encoded by NUSAP1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NUSAP1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of NUSAP1 was correlated with recurrence-free survival in patients with endometrial cancer. NUSAP1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ISG15 ubiquitin-like modifier in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ISG15 ubiquitin-like modifier, encoded by ISG15, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ISG15 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ISG15 was correlated with recurrence-free survival in patients with endometrial cancer. ISG15 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of non-SMC condensin I complex subunit G in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Mutational Burden ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified non-SMC condensin I complex subunit G, encoded by NCAPG, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. NCAPG was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, in human endometrial cancer, primary tumor expression of NCAPG was correlated with recurrence-free survival in white patients with low mutational burden. NCAPG may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of pituitary tumor-transforming 1 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Pituitary Tumor ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified pituitary tumor-transforming 1, encoded by PTTG1, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PTTG1 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of PTTG1 was correlated with recurrence-free survival in patients with endometrial cancer. PTTG1 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of PDZ binding kinase in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Free Survival ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified PDZ binding kinase, encoded by PBK, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. PBK was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of PBK was correlated with recurrence-free survival in patients with endometrial cancer. PBK may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of insulin degrading enzyme in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Clinical Problem ◽  
Insulin Degrading Enzyme ◽  
Normal Endometrium ◽  
Degrading Enzyme ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified the insulin degrading enzyme, encoded by IDE, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. IDE was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of IDE was correlated with overall survival in patients with endometrial cancer. IDE may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of structural maintenance of chromosomes 4 in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression ◽  
Structural Maintenance Of Chromosomes

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified structural maintenance of chromosomes 4, encoded by SMC4, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. SMC4 was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of SMC4 was correlated with overall survival in patients with endometrial cancer. SMC4 may be a molecule of interest in understanding the etiology or progression of human endometrial cancer.

scholarly journals Over-expression of ZW10 interacting kinetochore protein in human endometrial cancer.

2021 ◽  
Author(s):  
Shahan Mamoor
Keyword(s):  
Endometrial Cancer ◽  
Microarray Data ◽  
Clinical Problem ◽  
Normal Endometrium ◽  
Kinetochore Protein ◽  
Over Expression ◽  
Tumor Tissues ◽  
Endometrial Tumor ◽  
Endometrial Cancers ◽  
Tumor Expression

Gynecologic cancers including cancers of the endometrium are a clinical problem (1-4). We mined published microarray data (5, 6) to discover genes associated with endometrial cancers by comparing transcriptomes of the normal endometrium and endometrial tumors from humans. We identified ZW10 interacting kinetochore protein, encoded by ZWINT, as among the most differentially expressed genes, transcriptome-wide, in cancers of the endometrium. ZWINT was expressed at significantly higher levels in endometrial tumor tissues as compared to the endometrium. Importantly, primary tumor expression of ZWINT was correlated with overall survival in patients with endometrial cancer. ZWINT may be a molecule of interest in understanding the etiology and/or progression of human endometrial cancer.

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