scholarly journals Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion

2018 ◽  
Vol 39 (11) ◽  
pp. 2132-2139 ◽  
Author(s):  
M.T. Whitehead ◽  
A. Smitthimedhin ◽  
J. Webb ◽  
E.S. Mahdi ◽  
Z.P. Khademian ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Blood Flow ◽  
Cerebral Blood Flow ◽  
Bone Marrow Transplantation ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Marrow Transplantation

New insights into the pharmacokinetics of intravenous busulfan in children with sickle cell anemia undergoing bone marrow transplantation

2014 ◽  
Vol 62 (4) ◽  
pp. 680-686 ◽  
Author(s):  
Javid Gaziev ◽  
Antonella Isgrò ◽  
Alessia Francesca Mozzi ◽  
Aurèlie Petain ◽  
Laurent Nguyen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Marrow Transplantation

Bone marrow transplantation in a young child with sickle cell anemia

1995 ◽  
Vol 48 (4) ◽  
pp. 256-261 ◽  
Author(s):  
Karen A. Kalinyak ◽  
Christopher Morris ◽  
William S. Ball ◽  
M. Douglas Ris ◽  
Richard Harris ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Young Child ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Marrow Transplantation

Bone marrow transplantation for sickle cell anemia

1994 ◽  
Vol 124 (2) ◽  
pp. 329 ◽  
Author(s):  
C. Vermylen ◽  
G. Cornu ◽  
A. Ferster ◽  
E. Sariban
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Marrow Transplantation

scholarly journals Bone marrow transplantation corrects the splenic reticuloendothelial dysfunction in sickle cell anemia

Blood ◽  
1993 ◽  
Vol 81 (4) ◽  
pp. 1102-1105 ◽  
Author(s):  
A Ferster ◽  
W Bujan ◽  
F Corazza ◽  
C Devalck ◽  
P Fondu ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Transplantation ◽  
Sickle Cell ◽  
Sickle Cell Anemia ◽  
Marrow Transplantation ◽  
Blood Smear ◽  
Late Childhood ◽  
Blood Smears ◽  
Splenic Uptake ◽  
Organ Dysfunctions

In sickle cell anemia (SCA), the loss of reticuloendothelial function is the result of vasoocclusive events occurring in the spleen. Such asplenia occurs early in the course of the disease and is considered to be permanent in late childhood. In this report, three patients 10, 11, and 14 years of age suffering from severe SCA and found to be asplenic were treated by bone marrow transplantation (BMT). Before transplantation, all three patients had loss of reticuloendothelial splenic function, as assessed by the presence of abundant Howell-Jolly bodies on blood smears and absence of technetium 99m (99mTc) splenic uptake. After BMT, Howell-Jolly bodies disappeared from blood smear, whereas 99mTc isotopic scan found normal isotope uptake. Our data indicate that BMT can correct “permanent asplenia” in SCA patients. However, it remains to be determined if such treatment can also correct other SCA-related organ dysfunctions.

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