This technical paper provides instruction by example on how to apply hardware-in-the-loop (HIL) simulation for accelerated development of a complex control algorithm. The instruction provided in this technical paper is directed to HIL test bench setup, software, simulated and real hardware, and test methods. As an example, the authors reference their collaborative development project of the last couple of years, now completed. The objective of that project was to develop a demand-driven hydrogen production system and integrate it with a hydrogen-fueled internal combustion engine-powered vehicle test platform. The instruction provided in this technical paper is supported by data from the referenced project example.