Faculty Opinions recommendation of Potent, orally bioavailable calcitonin gene-related peptide receptor antagonists for the treatment of migraine: discovery of N-[(3R,6S)-6-(2,3-difluorophenyl)-2-oxo-1- (2,2,2-trifluoroethyl)azepan-3-yl]-4- (2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin- 1-yl)piperidine-1-carboxamide (MK-0974).

2008 ◽  
Author(s):  
Andrew Combs
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Orally Bioavailable

Discovery of potent, cyclic calcitonin gene-related peptide receptor antagonists

2011 ◽  
Vol 17 (5) ◽  
pp. 383-386 ◽  
Author(s):  
Liang Zeng Yan ◽  
Kirk W. Johnson ◽  
Emily Rothstein ◽  
David Flora ◽  
Patrick Edwards ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene

Orally bioavailable imidazoazepanes as calcitonin gene-related peptide (CGRP) receptor antagonists: Discovery of MK-2918

2011 ◽  
Vol 21 (9) ◽  
pp. 2683-2686 ◽  
Author(s):  
Daniel V. Paone ◽  
Diem N. Nguyen ◽  
Anthony W. Shaw ◽  
Christopher S. Burgey ◽  
Craig M. Potteiger ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Cgrp Receptor ◽  
Receptor Antagonists ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cgrp Receptor Antagonists ◽  
Orally Bioavailable

scholarly journals Anti‐migraine Calcitonin Gene–Related Peptide Receptor Antagonists Worsen Cerebral Ischemic Outcome in Mice

2020 ◽  
Vol 88 (4) ◽  
pp. 771-784 ◽  
Author(s):  
Inge A. Mulder ◽  
Mei Li ◽  
Tessa Vries ◽  
Tao Qin ◽  
Takeshi Yanagisawa ◽  
...  
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene ◽  
Cerebral Ischemic

Discovery techniques for calcitonin gene-related peptide receptor antagonists for potential antimigraine therapies

2013 ◽  
Vol 8 (11) ◽  
pp. 1309-1323 ◽  
Author(s):  
Sieneke Labruijere ◽  
Khatera Ibrahimi ◽  
Kayi Y Chan ◽  
Antoinette MaassenVanDenBrink
Keyword(s):  
Calcitonin Gene Related Peptide ◽  
Receptor Antagonists ◽  
Peptide Receptor ◽  
Related Peptide ◽  
Calcitonin Gene
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