Therapeutic Angiogenesis by Autologous Bone Marrow Cell Implantation for Refractory Chronic Peripheral Arterial Disease Using Assessment of Neovascularization by 99mTc-Tetrofosmin (TF) Perfusion Scintigraphy

2004 ◽  
Vol 13 (4) ◽  
pp. 429-438 ◽  
Author(s):  
Masaaki Miyamoto ◽  
Masahiro Yasutake ◽  
Hitoshi Takano ◽  
Hiromichi Takagi ◽  
Gen Takagi ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Marrow Cell ◽  
Autologous Bone Marrow ◽  
Arterial Disease ◽  
Therapeutic Angiogenesis ◽  
Perfusion Scintigraphy ◽  
99Mtc Tetrofosmin ◽  
Autologous Bone ◽  
Peripheral Arterial ◽  
Cell Implantation

scholarly journals Neovascularization Induced by Autologous Bone Marrow Cell Implantation in Peripheral Arterial Disease

2002 ◽  
Vol 11 (8) ◽  
pp. 747-752 ◽  
Author(s):  
Kensuke Esato ◽  
Kimikazu Hamano ◽  
Tao-Sheng Li ◽  
Akira Furutani ◽  
Atsushi Seyama ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Peripheral Arterial Disease ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Autologous Bone Marrow ◽  
Arterial Disease ◽  
Complete Healing ◽  
Autologous Bone ◽  
Peripheral Arterial ◽  
Cell Implantation

Neovascularization has recently been used as a new treatment for severe ischemic disease. We tried to induce therapeutic neovascularization by autologous bone marrow cell implantation (BMCI) in eight selected patients with chronic peripheral arterial disease (PAD), in whom traditional treatments had failed. Improvement of subjective symptoms was seen in seven patients after treatment. Of three limbs with toe or finger ulceration, complete healing was achieved in two, while the other one became less severe after treatment. No relative toxicity was observed in any of the patients. BMCI might be a feasible treatment for selected patients with chronic PAD.

Autologous bone marrow cell implantation as therapeutic angiogenesis for ischemic hindlimb in diabetic rat model

2003 ◽  
Vol 284 (1) ◽  
pp. H66-H70 ◽  
Author(s):  
Ken Hirata ◽  
Tao-Sheng Li ◽  
Masahiko Nishida ◽  
Hiroshi Ito ◽  
Masunori Matsuzaki ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cells ◽  
Marrow Cell ◽  
Autologous Bone Marrow ◽  
Therapeutic Angiogenesis ◽  
Endothelial Differentiation ◽  
Angiogenic Effect ◽  
Autologous Bone ◽  
Cell Implantation ◽  
Marrow Cells

The angiogenic effect induced by autologous bone marrow cell implantation (BMCI) was examined in the ischemic hindlimbs of diabetic and nondiabetic rats. Diabetes mellitus was induced by the systemic administration of streptozotocin. We investigated the production of angiogenic factors and endothelial differentiation from bone marrow cells and the native recovery of blood flow in the ischemic hindlimbs. To observe the angiogenic effect induced by BMCI treatment, 6 × 107 bone marrow cells were injected intramuscularly at six points into the ischemic limbs, and regional perfusion recovery was evaluated with colored microspheres 2 wk later. No difference was found between diabetic and nondiabetic rats in the release of angiogenic factors or endothelial differentiation from bone marrow cells in vitro. The levels of nitric oxide in plasma were significantly lower, and native perfusion recovery in the ischemic hindlimbs was significantly slower in the diabetic rats than in the nondiabetic rats. However, although perfusion recovery was achieved in the ischemic hindlimbs, there was no significant increase in systemic VEGF after BMCI treatment in either the diabetic or nondiabetic rats. Therefore, therapeutic angiogenesis induced by BMCI could be a safe and effective treatment for ischemic limb disease in diabetic patients.

Therapeutic angiogenesis induced by local autologous bone marrow cell implantation

2002 ◽  
Vol 73 (4) ◽  
pp. 1210-1215 ◽  
Author(s):  
Kimikazu Hamano ◽  
Tao-Sheng Li ◽  
Toshiro Kobayashi ◽  
Ken Hirata ◽  
Masafumi Yano ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Bone Marrow Cell ◽  
Marrow Cell ◽  
Autologous Bone Marrow ◽  
Therapeutic Angiogenesis ◽  
Autologous Bone ◽  
Cell Implantation
Sign in / Sign up

Export Citation Format

Share Document