Asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates with α-fluoro-β-keto esters
2013 ◽
Vol 9
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pp. 1853-1857
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Keyword(s):
In the presence of a commercially available Cinchona alkaloid as catalyst, the asymmetric allylic alkylation of Morita–Baylis–Hillman carbonates, with α-fluoro-β-keto esters as nucleophiles, have been successfully developed. A series of important fluorinated adducts, with chiral quaternary carbon centres containing a fluorine atom, was achieved in good yields (up to 93%), with good to excellent enantioselectivities (up to 96% ee) and moderate diastereoselectivities (up to 4:1 dr).
Keyword(s):
2018 ◽
Vol 59
(37)
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pp. 3401-3404
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Keyword(s):
2020 ◽
Vol 18
(24)
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pp. 4551-4555
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2017 ◽
Vol 359
(10)
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pp. 1735-1741
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Keyword(s):
2019 ◽
Vol 23
(11)
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pp. 1168-1213
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Keyword(s):