Extraglandular Manifestations in Korean Patients with Primary Sjögren's Syndrome

2015 ◽  
Vol 22 (3) ◽  
pp. 167 ◽  
Author(s):  
Byoong Yong Choi ◽  
Jong Jin Yoo ◽  
Hye Jin Oh ◽  
Yu Jin Jang ◽  
Yun Jong Lee ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Korean Patients ◽  
Extraglandular Manifestations ◽  
Sjögren‘S Syndrome

scholarly journals Discordant Predictions of Extraglandular Involvement in Primary Sjögren’s Syndrome According to the Anti-SSA/Ro60 Antibodies Detection Assay in a Cohort Study

2022 ◽  
Vol 11 (1) ◽  
pp. 242
Author(s):  
Geoffrey Urbanski ◽  
Aline Gury ◽  
Pascale Jeannin ◽  
Alain Chevailler ◽  
Pierre Lozac’h ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Extraglandular Manifestations ◽  
Antibodies Detection ◽  
Sjögren‘S Syndrome

Electrophoresis-derived techniques for anti-SSA/Ro60 KDa (anti-SSA) antibodies detection have been progressively replaced by methods using non-native antigens. We aimed to compare the patients’ phenotypes and the occurrence of extraglandular manifestations in primary Sjögren’s syndrome according to the method used to detect anti-SSA antibodies. Sera from patients with a diagnosis of pSS according to ACR/EULAR 2016 criteria between 2008 and 2017 were tested for anti-SSA antibodies using methods with non-native antigens (magnetic bead multiplex assay; line immunoassays) and one with native antigens (counterimmunoelectrophoresis (CIE)). The population was split into three groups according to anti-SSA antibodies status: absence (SSA−), presence in any method except for CIE (SSA+CIE−), and presence in CIE (SSA+CIE+). The patients in the SSA+CIE+ group (n = 70, 42.7%) were ten years younger and presented more immunological activity compared with both the SSA− (n = 80, 48.8%) and SSA+CIE− groups (n = 14, 8.5%). The SSA− and SSA+CIE− groups were poorly distinct. The presence of anti-SSA antibodies solely in CIE was significantly associated with the occurrence of extraglandular manifestations of pSS (HR = 4.45 (2.35–8.42)). Contrary to CIE, methods using non-native antigens to detect anti-SSA antibodies were unable to predict the occurrence of systemic expression of pSS.

scholarly journals Sjögren’s syndrome

2015 ◽  
Vol 62 (s11) ◽  
pp. 8-14
Author(s):  
V. Mlynáriková ◽  
D. Mičeková ◽  
J. Rovenský ◽  
E. Šteňová
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Inflammatory Rheumatic Diseases ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Extraglandular Manifestations ◽  
Sjögren‘S Syndrome

Abstract Sjögren’s syndrome is a slowly progressive, inflammatory autoimmune disease primarily affecting exocrine glands. Lymphocytic infiltrates replace functional epithelium and lead to decreased exocrine secretion of salivary and lacrimal glands - xerocrinopathy. Glands of intestinal system and pulmonary tract, skin and vaginal mucosa may also be affected. The most common extraglandular manifestations of primary Sjögren’s syndrome include skin vasculitis, Raynaud’s phenomenon, functional renal abnormalities, neuropathy and arthritis symptoms. This disorder may appear separately as a primary Sjögren’s syndrome or in connection with other inflammatory rheumatic diseases as secondary Sjögren’s syndrome. Treatment of the disease is based on topical ocular and oral therapy, extraglandular manifestations need to be treated with hydroxychloroquine and severe cases even with corticosteroid or immunosuppressive drugs.

Risk of malignancy in Korean patients with primary Sjögren's syndrome

2020 ◽  
Vol 23 (9) ◽  
pp. 1240-1247
Author(s):  
Juyeon Kang ◽  
Hyoungyoung Kim ◽  
Jinwook Kim ◽  
Seongmi Choi ◽  
Sun‐Young Jung ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Korean Patients ◽  
Risk Of Malignancy ◽  
Sjögren‘S Syndrome

scholarly journals Study on demography and outcome of extraglandular manifestations of primary sjögren's syndrome

2016 ◽  
Vol 11 (4) ◽  
pp. 202 ◽  
Author(s):  
Kavitha Mohanasundaram ◽  
Madeshwaran Mani ◽  
Saranaya Chinnadurai ◽  
Bhuvanesh Mahendran ◽  
Chilukuri Balaji ◽  
...  
Keyword(s):  
Sjögren’S Syndrome ◽  
Sjögren's Syndrome ◽  
Sjogren’S Syndrome ◽  
Sjogren's Syndrome ◽  
Primary Sjögren’S Syndrome ◽  
Primary Sjogren’S Syndrome ◽  
Primary Sjögren's Syndrome ◽  
Extraglandular Manifestations ◽  
Sjögren‘S Syndrome
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