scholarly journals Update on medical expulsive therapy for distal ureteral stones: Beyond alpha-blockers

2014 ◽  
Vol 8 (11-12) ◽  
pp. 442 ◽  
Author(s):  
Derek Bos ◽  
Anil Kapoor
Keyword(s):  
Best Practices ◽  
Ureteral Stones ◽  
Channel Blockers ◽  
Treatment Alternative ◽  
Pde5 Inhibitors ◽  
Initial Management ◽  
Medical Expulsive Therapy ◽  
Alpha Blockers ◽  
Novel Treatment ◽  
Phosphodiesterase 5

Medical expulsive therapy (MET) has been described as an effective conservative treatment option in the initial management of small distal ureteral stones. Therapies that have been investigated include alpha-blockers, calcium channel blockers, corticosteroids, and most recently phosphodiesterase-5 inhibitors (PDE5) inhibitors. While alpha-blockers are currently the only recommended monotherapy, corticosteroids have received increased attention as a potential useful adjunct in the medical management of distal stones. PDE5 inhibitors are a novel treatment alternative, requiring further investigation. This review provides an overview of recent MET best practices, with a focus on novel therapies beyond alpha blockers.

Alpha-blockers as medical expulsive therapy for ureteral stones

2010 ◽  
Author(s):  
Yefang Zhu ◽  
Maroeska M Rovers ◽  
Diederick Duijvesz ◽  
M T W Tycho Lock
Keyword(s):  
Ureteral Stones ◽  
Medical Expulsive Therapy ◽  
Alpha Blockers

Alpha-blockers as medical expulsive therapy for ureteral stones

2014 ◽  
Author(s):  
Thijs Campschroer ◽  
Yefang Zhu ◽  
Diederick Duijvesz ◽  
Diederick E Grobbee ◽  
M T W Tycho Lock
Keyword(s):  
Ureteral Stones ◽  
Medical Expulsive Therapy ◽  
Alpha Blockers

Medical Expulsive Therapy

2019 ◽  
Author(s):  
Mark Silva ◽  
Nina Mikkilineni ◽  
Ojas Shah
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Phosphodiesterase Inhibitors ◽  
Ureteral Stones ◽  
Channel Blockers ◽  
Medical Expulsive Therapy ◽  
Randomized Controlled ◽  
Meta Analyses ◽  
Pharmaceutical Agents ◽  
Stone Passage

Medical expulsive therapy (MET) for ureteral stones involves the administration of pharmaceutical agents to facilitate passage of stones by ideally increasing the rate of passage and reducing time for expulsion. Several medications have been studied for this use. The most commonly studied off-label medications include α1-antagonists and calcium channel blockers. This article reviews the data available for the use of MET and controversies in the use of medications to aid stone passage based on more recent randomized controlled trials and meta-analyses. Based on the latest guidelines, α-blockers have been the most studied medication type and may have some benefit in the passage of distal ureteral stones greater than 4 mm in size. This review contains 2 figures and 34 references. Keywords: α1-antagonists, α-blockers, calcium channel blockers, medical expulsion therapy, phosphodiesterase inhibitors, ureteral stones

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