Maternal serum screening for neural tube defects and Down's syndrome

1991 ◽  
Vol 155 (4) ◽  
pp. 280-280
Author(s):  
Paul T Dignam
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Maternal Serum Screening ◽  
Serum Screening

scholarly journals Maternal Serum Screening in Ontario Using the Triple Marker Test

2003 ◽  
Vol 10 (3) ◽  
pp. 107-111 ◽  
Author(s):  
A M Summers ◽  
S A Farrell ◽  
T Huang ◽  
C Meier ◽  
P R Wyatt
Keyword(s):  
Neural Tube ◽  
Neural Tube Defects ◽  
Large Scale ◽  
False Positive Rate ◽  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Trisomy 18 ◽  
Maternal Serum Screening ◽  
Serum Screening

Objectives: To summarise the experience and evaluate the performance of the Ontario maternal serum screening (MSS) programme. Methods: This study used information collected in the Ontario MSS database, which contains data on each screened pregnancy. In the Ontario MSS programme, women are screened between 15 and 20 weeks of gestation. The risk cut-off for Down's syndrome was ≥1 in 385 at term and women with a serum alpha-fetoprotein ≥2.2 multiples of the unaffected population median were defined as screen-positive for open neural tube defects. Results: Between 1 October 1993 and 30 September 2000, 428,410 women residing in Ontario were screened for open neural tube defects, and 423,895 women were screened for Down's syndrome and trisomy 18. Approximately 48% of all pregnant women in the province had MSS. The uptake rate of amniocentesis following a positive Down's syndrome screening was 67%. Of 717 cases of Down's syndrome ascertained in the screened population, 531 were detected by MSS, giving a term detection rate (DR) of 70.6%, with a false-positive rate (FPR) of 7.2%. For neural tube defects, the DRwas 72.7%, with a FPR of 2.0%. The screen also detected 50% of cases of trisomy 18 at term, with a FPR of 0.2%. Coincidentally, 113 cases of chromosome aneuploidies other than Down's syndrome and trisomy 18 were detected Discussion: In the Ontario MSS programme, MSS performed as expected in the detection of Down's syndrome, open neural tube defects and trisomy 18. MSS is an effective and practical method for large- scale second ttrriimester screeni.ng for Down's syndrome, open neuraI tube defects and ttrriisomy 18, and the MSS database is an extremely useful tool in monitoring the performance of this screen.

Maternal serum screening for Down's syndrome

Public Health ◽  
1997 ◽  
Vol 111 (6) ◽  
pp. 383-385
Author(s):  
S Fairgrieve ◽  
D Magnay ◽  
I White ◽  
J Burn
Keyword(s):  
Down's Syndrome ◽  
Down’S Syndrome ◽  
Maternal Serum ◽  
Maternal Serum Screening ◽  
Serum Screening
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