In this article, by using the notions of contingent derivative, contingent epiderivative and generalized contingent epiderivative, we obtain some characterizations of the Lagrange multiplier rule at points which are not necessarily local minima.
The notions of higher-order weakly generalized contingent epiderivative and higher-order weakly generalized adjacent epiderivative for set-valued maps are proposed. By virtue of the higher-order weakly generalized contingent (adjacent) epiderivatives, both necessary and sufficient optimality conditions are obtained for Henig efficient solutions to a set-valued optimization problem whose constraint set is determined by a set-valued map. The imposed assumptions are relaxed in comparison with those of recent results in the literature. Examples are provided to show some advantages of our notions and results.