Anemie emolitiche da anomalie ereditarie dell'Hb.

SUMMARYNew researches have made it evident that besides the two normal Hb, the adult one (a) and the phoetal (f), there are other pathologic Hb:c, e, s, d, g, h, i.These Hb, excepting theh, are present in the hetherozygote on every healthy person and in the homozygote, excepting thegHb, determine chronic hemolitic anemia.ThefHb, or a very similar Hb, is present in the Thalassemia minor and major, in some homozygote cases of abnormal Hb, in the interreaction between two different genes of these Hb, or between one of these genes with the one of Thalassemia.We may retain that the genesa, c, s, d, e, g, i, form an allelomorphic series. The geneThis not a part of this series.Since in the homozygotesss, cc(in absence of the genea) the quantity of abnormal Hb does not always reach the same percentage, we may logically retain that the different quantity of abnormal Hb possessed by thesandchetherozygotes depends from the different synthetic capacity of the genes of the two abnormal Hb. The appareance offHb may be the expression of a phenomenon of physiopatological compensation, which occurs when Hbaformation is prevented.

The Recognition of Four Red Cell Antigen-Antibody Systems in the Rabbit

SummaryFour red cell antigen-antibody systems in the rabbit are described.Three of these systems, Z, Y and W, appear to be inherited as an allelomorphic series. The fourth is inherited independently.Some of the serological properties which allow these sera to be recognized are described and attention is drawn to a property of rabbit red cells, manifested by a variation in their susceptibility to agglutination by homologous antisera, which can complicate the separation of a mixture of antibodies in one serum.