scholarly journals A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

2021 ◽  
Vol 5 ◽  
pp. 239784732199587
Author(s):  
Ashutosh Kumar ◽  
Ulrike Kogel ◽  
Marja Talikka ◽  
Celine Merg ◽  
Emmanuel Guedj ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Clinical Signs ◽  
Inhalation Study ◽  
Toxicology Study ◽  
Nasal Tissue ◽  
Product Switching ◽  
The Impact

Cigarette smoking causes serious diseases, including lung cancer, atherosclerotic coronary artery disease, peripheral vascular disease, chronic bronchitis, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine-containing products may reduce disease risks among those unable or unwilling to quit. E-vapor aerosols typically contain significantly lower levels of smoke-related harmful and potentially harmful constituents; however, health risks of long-term inhalation exposures are unknown. We designed a 7-month inhalation study in C57BL/6 mice to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation (Cessation group) or switching to an e-vapor product (Switching group) after 3 months of exposure to 3R4F cigarette smoke (CS). There were no significant changes in in-life observations (body weights, clinical signs) in e-vapor groups compared to the Sham Control. The 3R4F CS group showed reduced respiratory function during exposure and had lower body weight and showed transient signs of distress post-exposure. Following 7 months of exposure, e-vapor aerosols resulted in no or minimal increase in pulmonary inflammation, while exposure to 3R4F CS led to impairment of lung function and caused marked lung inflammation and emphysematous changes. Biological changes observed in the Switching group were similar to the Cessation group. 3R4F CS exposure dysregulated the lung and nasal tissue transcriptome, while these molecular effects were substantially lower in the e-vapor group. Results from this study demonstrate that in comparison with 3R4F CS, e-vapor aerosols induce substantially lower biological responses including pulmonary inflammation and emphysematous changes, and that complete switching from CS to e-vapor products significantly reduces biological changes associated with CS in C57BL/6 mice.

The impact of psychosocial characteristics in predicting smoking cessation in long-term cancer survivors: A time-to-event analysis

2018 ◽  
Vol 27 (10) ◽  
pp. 2458-2465 ◽  
Author(s):  
Yael R. Symes ◽  
J. Lee Westmaas ◽  
Deborah K. Mayer ◽  
Marcella H. Boynton ◽  
Kurt M. Ribisl ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cancer Survivors ◽  
Event Analysis ◽  
Time To Event ◽  
Psychosocial Characteristics ◽  
The Impact

scholarly journals Lifestyle and Long-Term Smoking Cessation

2020 ◽  
Vol 13 ◽  
pp. 1179173X2096306
Author(s):  
Tove Sohlberg ◽  
Karin Helmersson Bergmark
Keyword(s):  
Smoking Cessation ◽  
Smoking Initiation ◽  
Lifestyle Changes ◽  
Factors Affecting ◽  
Quit Smoking ◽  
Swedish Health Care ◽  
The Impact ◽  
Term Maintenance

Background: Since smoking is the leading cause of preventable death, discouraging smoking initiation, encouraging smoking cessation, and exploring factors that help individuals to stay smoke free are immensely important. One such relevant factor may be the impact of lifestyle for long-term smoking cessation. Method: A representative sample of successful quitters was recruited for a study about smoking cessation. These respondents are now part of a 7-year follow-up with the overall aim of revealing factors affecting long-term smoking cessation. Descriptive analyses were carried out at baseline and at follow-up, as well as a further two-step cluster analysis to explore profiles of long-term smoke-free individuals. Results: A majority did not make any particular lifestyle changes, but among those who did, most adopted a healthier lifestyle and/or increased their quota of physical training, where permanent changes in this direction seem to promote a more enduring smoke-free life. Conclusions: Individuals who want to quit smoking should be encouraged to increase their level of physical activity. Swedish health care institutions should be able to provide support for this both initially and over time to promote the long-term maintenance of a smoke-free lifestyle.

Chronic Inhalation Toxicity of Fibrous Glass in Rats and Monkeys

1986 ◽  
Vol 5 (6) ◽  
pp. 545-575 ◽  
Author(s):  
R. I. Mitchell ◽  
D. J. Donofrio ◽  
W. J. Moorma
Keyword(s):  
Clinical Signs ◽  
Inhalation Toxicity ◽  
Potential Health ◽  
Inhalation Study ◽  
Pleural Plaques ◽  
Body Weights ◽  
Table Analysis ◽  
F344 Rats ◽  
Macrophage Aggregates

Numerous reports have shown that fibrous glass has the potential to cause fibrogenic and carcinogenic responses in test animals. The experiments producing significant response have, however, used unrealistic routes of exposure. The increased demand for fibrous glass for insulating purposes where respirable fibers may exist presents considerable concern for potential health problems. Therefore, a long-term inhalation study was conducted with F344 rats and cynomolgus monkeys exposed in treatments characterized by fibers of varying geometry and mass concentrations. A workweek type of exposure (7 hours/day, 5 days/week) was maintained for 18 months with monkeys and 21 months with rats, which were subsequently held to 80% mortality. The evaluation of response included life table analysis, body weights, clinical signs, hematological testing, respiratory function, ophthalmic examinations, clinical biochemical analysis, and gross and microscopic pathological examinations. Both species demonstrated pulmonary macrophage aggregates and granulomas containing fibrous glass. The rats had grossly visible pleural plaques, which were not seen in the monkeys. There was no evidence of pulmonary or mesothelial carcinogenicity or fibrogenicity in either species. There were no other significant responses with the exception of a statistically increased mononuclear cell leukemia in each fiber-exposed rat group.

scholarly journals Discriminating Spontaneous From Cigarette Smoke and THS 2.2 Aerosol Exposure-Related Proliferative Lung Lesions in A/J Mice by Using Gene Expression and Mutation Spectrum Data

2021 ◽  
Vol 3 ◽  
Author(s):  
Yang Xiang ◽  
Karsta Luettich ◽  
Florian Martin ◽  
James N. D. Battey ◽  
Keyur Trivedi ◽  
...  
Keyword(s):  
Gene Expression ◽  
Cigarette Smoke ◽  
Human Lung ◽  
Gene Signature ◽  
Lung Tumors ◽  
Tumor Classification ◽  
Spontaneous Tumors ◽  
Data Set ◽  
Inhalation Study ◽  
The Impact

Mice, especially A/J mice, have been widely employed to elucidate the underlying mechanisms of lung tumor formation and progression and to derive human-relevant modes of action. Cigarette smoke (CS) exposure induces tumors in the lungs; but, non-exposed A/J mice will also develop lung tumors spontaneously with age, which raises the question of discriminating CS-related lung tumors from spontaneous ones. However, the challenge is that spontaneous tumors are histologically indistinguishable from the tumors occurring in CS-exposed mice. We conducted an 18-month inhalation study in A/J mice to assess the impact of lifetime exposure to Tobacco Heating System (THS) 2.2 aerosol relative to exposure to 3R4F cigarette smoke (CS) on toxicity and carcinogenicity endpoints. To tackle the above challenge, a 13-gene gene signature was developed based on an independent A/J mouse CS exposure study, following by a one-class classifier development based on the current study. Identifying gene signature in one data set and building classifier in another data set addresses the feature/gene selection bias which is a well-known problem in literature. Applied to data from this study, this gene signature classifier distinguished tumors in CS-exposed animals from spontaneous tumors. Lung tumors from THS 2.2 aerosol-exposed mice were significantly different from those of CS-exposed mice but not from spontaneous tumors. The signature was also applied to human lung adenocarcinoma gene expression data (from The Cancer Genome Atlas) and discriminated cancers in never-smokers from those in ever-smokers, suggesting translatability of our signature genes from mice to humans. A possible application of this gene signature is to discriminate lung cancer patients who may benefit from specific treatments (i.e., EGFR tyrosine kinase inhibitors). Mutational spectra from a subset of samples were also utilized for tumor classification, yielding similar results. “Landscaping” the molecular features of A/J mouse lung tumors highlighted, for the first time, a number of events that are also known to play a role in human lung tumorigenesis, such as Lrp1b mutation and Ros1 overexpression. This study shows that omics and computational tools provide useful means of tumor classification where histopathological evaluation alone may be unsatisfactory to distinguish between age- and exposure-related lung tumors.

Promoting Health and Physical Function Among Cancer Survivors: Potential for Prevention and Questions That Remain

2006 ◽  
Vol 24 (32) ◽  
pp. 5125-5131 ◽  
Author(s):  
Wendy Demark-Wahnefried ◽  
Bernardine M. Pinto ◽  
Ellen R. Gritz
Keyword(s):  
Physical Activity ◽  
Smoking Cessation ◽  
Cancer Survivors ◽  
Physical Function ◽  
Behavioral Change ◽  
Exercise Interventions ◽  
Increased Risk ◽  
Health Related ◽  
The Impact

Cancer survivors are at increased risk, not only for progressive and recurrent disease, but also other cancers, cardiovascular disease, diabetes, osteoporosis, and functional decline. Lifestyle interventions to improve dietary and physical activity behaviors, and smoking cessation, have the potential to improve the overall health and quality of life of this vulnerable population. Studies on overall health and physical function from 1966 and beyond regarding the impact of behavioral interventions that used randomized and controlled designs were identified through MEDLINE and PubMed searches. Published reports currently exist for 22 exercise interventions, 11 diet-related interventions (excluding those limited to dietary supplements or single nutrients), two diet and exercise interventions, and 10 behavioral-based smoking cessation interventions. Although many interventions have been successful in promoting behavioral change and have resulted in improvements in various health-related outcomes, more research is needed to determine the key components of interventions that are able to produce the greatest behavioral change and the most favorable health-related benefits. The oncology care provider can play a pivotal role in improving the long-term health of cancer survivors by (1) being aware of opportunities to encourage healthful behaviors (ie, smoking cessation, weight control, and increased physical activity); (2) vigilantly tracking long-term effects among cancer survivors and exploring whether they are amenable to intervention; (3) staying abreast of current health behavior guidelines for cancer survivors and existing resources for professional and patient education; and (4) supporting and contributing to efforts aimed at primary and tertiary prevention research.

scholarly journals Electronic cigarettes and health with special focus on cardiovascular effects: position paper of the European Association of Preventive Cardiology (EAPC)

2020 ◽  
pp. 204748732094199
Author(s):  
Maryam Kavousi ◽  
Charlotta Pisinger ◽  
Jean-Claude Barthelemy ◽  
Delphine De Smedt ◽  
Konstantinos Koskinas ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Tobacco Smoking ◽  
European Association ◽  
Electronic Cigarettes ◽  
Cardiovascular Effects ◽  
Position Paper ◽  
Cigarette Use ◽  
Preventive Cardiology ◽  
The Impact

Background Tobacco use is the single largest preventable risk factor for premature death of non-communicable diseases and the second leading cause of cardiovascular disease. In response to the harmful effects of tobacco smoking, the use of electronic cigarettes (e-cigarettes) has emerged and gained significant popularity over the past 15 years. E-cigarettes are promoted as safe alternatives for traditional tobacco smoking and are often suggested as a way to reduce or quit smoking. However, evidence suggests they are not harmless. Discussion The rapid evolution of the e-cigarette market has outpaced the legislator’s regulatory capacity, leading to mixed regulations. The increasing use of e-cigarettes in adolescents and young individuals is of concern. While the long-term direct cardiovascular effects of e-cigarettes remain largely unknown, the existing evidence suggests that the e-cigarette should not be regarded as a cardiovascular safe product. The contribution of e-cigarette use to reducing conventional cigarette use and smoking cessation is complex, and the impact of e-cigarette use on long-term cessation lacks sufficient evidence. Conclusion This position paper describes the evidence regarding the prevalence of e-cigarette smoking, uptake of e-cigarettes in the young, related legislations, cardiovascular effects of e-cigarettes and the impact of e-cigarettes on smoking cessation. Knowledge gaps in the field are also highlighted. The recommendations from the population science and public health section of the European Association of Preventive Cardiology are presented.

scholarly journals Impacts of peroxisome proliferator-activated receptor-γ activation on cigarette smoke-induced exacerbated response to bacteria

2014 ◽  
Vol 45 (1) ◽  
pp. 191-200 ◽  
Author(s):  
Mathieu C. Morissette ◽  
Pamela Shen ◽  
Danya Thayaparan ◽  
Martin R. Stämpfli
Keyword(s):  
Cigarette Smoke ◽  
Treatment Options ◽  
Pulmonary Inflammation ◽  
Treatment Protocol ◽  
Bacterial Pathogen ◽  
Chronic Obstructive ◽  
Peroxisome Proliferator ◽  
Peroxisome Proliferator Activated Receptor ◽  
Ppar Γ ◽  
The Impact

Chronic obstructive pulmonary disease (COPD) is characterised by a state of chronic pulmonary inflammation punctuated by microbial exacerbations. Despite advances in treatment options, COPD remains difficult to manage. In this study, we investigated the potential of peroxisome proliferator-activated receptor (PPAR)γ activation as a new therapy against cigarette smoke-induced inflammation and its associated bacterial exacerbation.C57BL/6 mice were exposed to room air or cigarette smoke for either 4 days or 4 weeks and treated either prophylactically or therapeutically with rosiglitazone. The impact of rosiglitazone on cigarette smoke-induced exacerbated response to the bacterial pathogen nontypeable Haemophilus influenzae (NTHi) was studied using the therapeutic treatment protocol.We found that rosiglitazone was able to reduce cigarette smoke-induced neutrophilia both when administered prophylactically or therapeutically. Therapeutic intervention with rosiglitazone was also effective in preventing cigarette smoke-induced neutrophilia exacerbation following NTHi infection. Moreover, the anti-inflammatory effects of rosiglitazone did not lead to an increase in the pulmonary bacterial burden, unlike dexamethasone.Altogether, our data suggest that pharmacological activation of PPARγ may be an effective therapeutic approach to improve COPD management, as it is able to reduce cigarette smoke-induced inflammation and decrease the magnitude of bacterial exacerbations, without compromising the ability of the immune system to control the infection.

Efficacy of Pins and Diplomas as a Reward for Long-Term Smoking Cessation

2009 ◽  
Vol 95 (3) ◽  
pp. 286-290 ◽  
Author(s):  
Elena Munarini ◽  
Cinzia De Marco ◽  
Edoardo Rossetti ◽  
Giovanni Invernizzi ◽  
Ario A Ruprecht ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Self Esteem ◽  
Patient Relationship ◽  
Multiple Choice Questionnaire ◽  
Smoking Withdrawal ◽  
One Year ◽  
Diploma Program ◽  
The Impact ◽  
Official Recognition

Aims and background Since 2004, the Antismoking Center of the National Cancer Institute of Milan has rewarded those who have been ex-smokers for longer than a year with a “former smoker” pin and a diploma. We investigated firstly whether these rewards contributed to maintain smoking withdrawal, secondly, which one of these was more appreciated and why, and thirdly, how they may have influenced the ex-smokers' perception of smoking and how this was reflected on those surrounding them (i.e., ex-smokers' personal and/or interpersonal areas). Methods A multiple-choice questionnaire was developed to investigate how much the rewards were appreciated and their effectiveness in maintaining smoking cessation. Moreover, smokers and non-smokers were asked about the impact of the pin. The questionnaire was completed on the phone by the last 100 ex-smokers who entered the pin and diploma program. Results All subjects appreciated the rewards, but only a few of them considered them as an aid to maintain long-term smoking cessation. Those who preferred the diploma stated that it represented a contribution to their self-esteem, an official recognition of being an ex-smoker, besides being something to show with pride to others. Those who preferred the pin principally stated it allowed them to be an example to other smokers. Most of the subjects reported that they wore the pin in several circumstances, raising interest and admiration. Conclusions Rewarding ex-smokers one year after smoking cessation with a small prize may be a useful practice to improve the doctor-patient relationship, which is vital to maintain smoking cessation, and to boost the awareness of the availability of aids to reach this objective.

Management of muscle-invasive bladder cancer with bladder preservation in Russia: A survey-based analysis of current practice and the impact of an educational workshop on clinical expertise.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. 10509-10509
Author(s):  
Natalia Dengina ◽  
Marina Chernich ◽  
Sergey Usychkin ◽  
Catherine Degnin ◽  
Yiyi Chen ◽  
...  
Keyword(s):  
Bladder Cancer ◽  
Smoking Cessation ◽  
Practice Patterns ◽  
Invasive Bladder Cancer ◽  
Muscle Invasive Bladder Cancer ◽  
Bladder Preservation ◽  
Mcnemar Test ◽  
Muscle Invasive ◽  
The Impact

10509 Background: Trimodality bladder preservation (BP) is an accepted alternative to radical cystectomy for patients with muscle-invasive bladder cancer (MIBC). The global utilization of BP is variable, and practice patterns have not been previously studied in Russia. During the Russian Annual Oncology Congress, organized by the Russian Society of Clinical Oncology in November 2018, our group has conducted a contouring workshop for Russian radiation oncologists (ROs). We sought to elucidate the contemporary practice patterns in Russia and determine the impact of this workshop on attitudes of Russian ROs towards BP. Methods: Pre- and post-workshop IRB-approved surveys were analyzed to determine baseline clinical experience and patterns of care among Russian ROs. The effect of the contouring workshop on participants’ knowledge and attitudes was performed using tests for paired nominal data. Results: We analyzed 77 pre-workshop and 32 matched post-workshop questionnaires. 56% (43 out of 77) of respondents treated MIBC patients with bladder-directed radiation therapy (RT). Of these, 40% (17 out of 43) treated only inoperable patients, and 60% treated both operable and inoperable MIBC patients. 14% offered RT alone to their patients, while the rest offered concurrent chemoRT. 63% (26 out of 41) offered suboptimal concurrent systemic agents, such as single agents carboplatin or paclitaxel. 63% of respondents felt that BP can only be done in specialized centers with established expertise, but only 10% felt uncomfortable offering an MIBC patient a BP option in their clinic. Prior to workshop, 40% of respondents estimated universal poor bladder and erectile functions after BP. The workshop resulted in dramatic change in participants’ attitudes towards BP long-term urinary (Stuart-Maxwell-test, p < 0.01), and sexual (exact McNemar test, p < 0.01) side-effects. Prior to workshop, only 52% of respondents routinely discussed smoking cessation (SC) with their patients, whereas after workshop almost 90% agreed that SC discussion is mandatory (exact McNemar test, p = 0.04). Conclusions: Bladder preservation is commonly used in Russia in the management of MIBC patients. Our contouring workshop resulted in dramatically improved understanding of long-term BP toxicities and inspired Russian ROs to incorporate smoking cessation counseling into routine clinical practice. International educational efforts are critical to improve multi-disciplinary management of MIBC patients.

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