Sudan stand-off will persist beyond Hamdok’s exit

Significance His departure is ostensibly a blow for Sudan’s military leaders and a symbolic victory for Sudanese calling for the military to leave power. However, the stand-off between the two groups remains fundamentally unchanged. Impacts If leaders cannot find enough civilians to form a cabinet, they may offer some posts to serving or retired military. Protests and possible strike action will continue but may have only limited impact, unless rising casualties trigger a new flashpoint. Significant new international sanctions are unlikely to materialise.

Nigeria finance bill will modestly increase revenue

Significance The bill aims to expand the accruable revenue for the federal government, crucial for meeting the government’s 2022 fiscal targets. In particular it looks to close existing tax loopholes rather than raising consumption taxes which could inhibit economic growth. Impacts Increased taxes will only have a limited impact on consumer spending and inflation. The bill will not appreciably increase state-level revenues. Broader institutional reforms in the public sector are unlikely due to powerful patronage networks.

Vaccines for Mycoplasma Diseases of Small Ruminants: A Neglected Area of Research

Mycoplasmas cause some of the most economically important diseases of sheep and goats, including diseases listed by the World Organisation for Animal Health (OIE) such as contagious caprine pleuropneumonia (CCPP) and contagious agalactia (CA). Other important mycoplasma diseases include chronic respiratory and arthritic syndrome (CRAS) and atypical pneumonia, both present on all continents where small ruminants are farmed. Unfortunately, owing to a lack of investment, most commercial vaccines for these diseases are of poor quality, being mostly composed of killed bacteriocins of dubious or unknown efficacy. Several Mediterranean laboratories produce autogenous vaccines, but these can only be used on farms where outbreaks have been officially declared, and consequently have limited impact on disease nationally. Effective live vaccines are available, but their use is often restricted because of safety concerns. With the necessary safeguards in place, we argue for their greater use. This review examines reported vaccines for mycoplasma diseases of small ruminants and attempts to identify new candidate antigens that may enable the development of improved products. Vaccines for CCPP are covered elsewhere.

Effects of milking, over-milking and vacuum levels on front and rear quarter teats in dairy cows

Mechanical forces to the teat and vacuum during milking negatively affect teat condition and may result in increased mastitis risk. We compared vacuum levels during milking and over-milking as well as teat condition before and after milking between front and rear teats. We expected that the lower milk yield of the front quarters would result in a longer over-milking and higher vacuum levels in front teats, resulting in morphological differences. The study comprised 540 dairy cows in 41 Austrian dairy farms with conventional milking systems. Before and after milking teats were visually assessed (colour, swelling, rings, hyperkeratosis) and teat dimensions (length, diameter, wall thickness, teat canal length) were measured manually and ultrasonographically. Vacuum measurements were taken using a vacuum measurement device attached to the cluster (short milk tube, pulsation tube and mouth-piece chamber). These various measurements of front and rear teats were compared and a multivariable analysis with backward stepwise procedure was used for inclusion or exclusion from the model. Front teats showed a poorer teat condition and were over-milked for longer in comparison to the rear teats. However, during milking and over-milking the vacuum levels in the mouthpiece chamber were significantly higher at the rear teats. The changes in front teat morphology were only partially caused by milking, over-milking and vacuum levels, with approximately 70% of the variation due to other, undetermined variables. Milking, over-milking and vacuum levels had no or very limited impact on the morphological changes of the rear teats.

US sanctions on spyware vendors have limited impact

Headline US: Sanctions on spyware vendors have limited impact

Guinea: ECOWAS pressure will have a limited impact

Headline GUINEA: ECOWAS pressure will have a limited impact

Concluding Reflections: Towards Alternative Peri-Urban Futures?

This final chapter summarizes the main contributions of the book and provides some ideas on carrying forward the research and action research agenda presented in this book. The peri-urban requires concerted engagement and new, transformative, policy approaches. Continued reliance on formal policy approaches is likely to have only a limited impact or even to be counterproductive. Strong partnerships across academics and civil society organizations are required in order to create a stronger scientific discourse on the peri-urban, as well as to catalyze changes within and beyond peri-urban spaces. While selective state apathy towards the peri-urban needs correction, the messy and transitory nature of peri-urban spaces will require engagements across a wide spectrum of actors beyond the state. An understanding of these approaches is necessary before prescribing “policy reforms” for the peri-urban.

Lebanese Palestinian jobs move may have limited impact

Headline LEBANON: Palestinian jobs move may have limited impact

Clinical and genomic signatures of rising SARS-CoV-2 Delta breakthrough infections in New York

In 2021, Delta has become the predominant SARS-CoV-2 variant worldwide. While vaccines effectively prevent COVID-19 hospitalization and death, vaccine breakthrough infections increasingly occur. The precise role of clinical and genomic determinants in Delta infections is not known, and whether they contribute to increased rates of breakthrough infections compared to unvaccinated controls. Here, we show a steep and near complete replacement of circulating variants with Delta between May and August 2021 in metropolitan New York. We observed an increase of the Delta sublineage AY.25, its spike mutation S112L, and nsp12 mutation F192V in breakthroughs. Delta infections were associated with younger age and lower hospitalization rates than Alpha. Delta breakthroughs increased significantly with time since vaccination, and, after adjusting for confounders, they rose at similar rates as in unvaccinated individuals. Our data indicate a limited impact of vaccine escape in favor of Delta’s increased epidemic growth in times of waning vaccine protection.