Flexibility in the social structure of male chimpanzees (Pan troglodytes schweinfurthii) in the Budongo Forest, Uganda

ABSTRACTIndividuals of social species face a trade-off between the competitive costs and social benefits of group living. Species show a range of social strategies to deal with this trade-off, for example atomistic fission-fusion dynamics in which temporary social groups of varying size and membership form and re-form; or molecular fission-fusion dynamics which contain stable sets of multilevel nested subgroups. Chimpanzees are considered an archetypical atomistic fission-fusion species, using dynamic changes in day-to-day association to moderate the costs of within-group competition. It has been argued that humans’ highly flexible social organisation allows us to live in extremely large groups. Using four years of association data from two neighbouring communities of East African chimpanzees (Pan troglodytes schweinfurthii), we describe new levels of flexibility in chimpanzee social organisation and confirm the presence of subgrouping in a second, large community of chimpanzees. We show that males from the larger Waibira community (N males 24-31) exhibited additional levels of semi-stable subgrouping, while males from the smaller Sonso community (N males 10-13) did not. Subgroup membership showed stability across some years, but flexibility across others. Our data support the hypothesis that chimpanzees can incorporate strategies other than fission-fusion to overcome costs of social living, and that their social organisation may be closer to that of modern humans than previously described.SIGNIFICANCE STATEMENTSocial living offers benefits and costs; groups can more easily locate and defend resources, but experience increased individual competition. Many species, or individuals, flexibly adjust their social organization when faced with different competitive pressures. It is argued that humans are unique among primates in combining multigroup social organisation with fission-fusion dynamics flexibly within and across groups, and that doing so allows us to live in extremely large groups. Using four-years of association data we show new levels of flexibility in chimpanzee social organization. Males from a typically-sized community employed atomistic fission-fusion dynamics, but males in an unusually large community incorporated additional semi-stable levels of subgrouping. Our data support the hypothesis that chimpanzee males combine social organization strategies, and that doing so may allow them, like humans, to mitigate individual costs at larger community sizes.

Impact of individual-level characteristics and transmission mitigation behaviors on SARS-CoV-2 infection and seroprevalence in a large Northern California Bay Area cohort

Comprehensive data on transmission mitigation behaviors and SARS-CoV-2 infection and serostatus are needed from large, community-based cohorts to identify SARS-CoV-2 risk factors and impact of public health measures. From July 2020 to March 2021, ≈5,500 adults from the East Bay Area, California were followed over three data collection rounds. We estimated the prevalence of antibodies from SARS-CoV-2 infection and COVID-19 vaccination, and self-reported COVID-19 test positivity. Population-adjusted SARS-CoV-2 seroprevalence was low, increasing from 1.03% (95% CI: 0.50-1.96) in Round 1 (July-September 2020), to 1.37% (95% CI: 0.75-2.39) in Round 2 (October-December 2020), to 2.18% (95% CI: 1.48-3.17) in Round 3 (February-March 2021). Population-adjusted seroprevalence of COVID-19 vaccination was 21.64% (95% CI: 19.20-24.34) in Round 3. Despite >99% of participants reporting wearing masks, non-Whites, lower-income, and lower-educated individuals had the highest SARS-CoV-2 seroprevalence and lowest vaccination seroprevalence. Our results demonstrate that more effective policies are needed to address these disparities and inequities.

Patterns of negative affective biases associated with depressive symptoms and during remission in large community-based sample

Background: Major Depressive Disorder (MDD) is associated with negative affective cognitive biases. Differences on population level however remain unclear, including whether they normalise with remission. This study investigated associations between affective cognition and MDD within a large community-based sample.Methods: Participants from Generation Scotland (N=1,179) completed three affective tasks: (i) Bristol Emotion Recognition Task (BERT), (ii) Face Affective Go/No-go (FAGN), and (iii) Cambridge Gambling Task (CGT). After exclusions, individuals were classified as MDD-current (n=43), MDD-remitted (n=282), or non-MDD controls (n=784). Main analyses tested for hypothesised associations between affective bias summary measures and depressive symptoms, and for differences in affective biases between MDD-remitted versus non-MDD subjects. Exploratory analyses examined responses per task condition in more detail.Results: We found an association between greater depressive symptom severity and lower risk adjustment (CGT win, standardised coefficient =-0.02, p=0.03). This was attenuated when non-affective cognition (g) was accounted for, or when restricting analysis to those not currently taking antidepressant medication. Main analysis revealed no further clear evidence of affective biases, neither for MDD-remitted individuals. Exploratory analyses however suggested more subtle negative biases associated with depressive symptoms.Conclusions: Individuals with high depressive ratings were less likely to bet more despite increasingly favourable win conditions, which may indicate lower reward motivation, but could also be explained by lower non-affective cognitive functioning. Overall, results from this community-based sample showed limited evidence for overarching cognitive affective differences in MDD, though subtle negative biases related to current symptom severity suggested by exploratory analyses across the whole sample.

Evaluation of a capped dosing telavancin regimen compared to standard dosing at a large community teaching hospital

Telavancin, a lipoglycopeptide antibiotic, is traditionally dosed as 10 mg/kg based on total body weight, but is associated with toxicities that limit its use. This study supports the use of a capped dosing regimen of 750 mg in obese patients, which is associated with equal efficacy and fewer adverse effects compared to traditional dosing.

A Safe Collaborative Chatbot for Smart Home Assistants

Smart home assistants, which enable users to control home appliances and can be used for holding entertaining conversations, have become an inseparable part of many people’s homes. Recently, there have been many attempts to allow end-users to teach a home assistant new commands, responses, and rules, which can then be shared with a larger community. However, allowing end-users to teach an agent new responses, which are shared with a large community, opens the gate to malicious users, who can teach the agent inappropriate responses in order to promote their own business, products, or political views. In this paper, we present a platform that enables users to collaboratively teach a smart home assistant (or chatbot) responses using natural language. We present a method of collectively detecting malicious users and using the commands taught by the malicious users to further mitigate activity of future malicious users. We ran an experiment with 192 subjects and show the effectiveness of our platform.

Establishing the need for provider education on cancer and nutrition (PECAN): Survey results on nutrition practices at a large community oncology practice.

49 Background: Oncology providers and patients benefit from evidence-based nutritional resources to support cancer care. For patients, proper nutrition care can prevent inappropriate weight loss, improve treatment tolerance, and improve quality of life. Recent literature has noted the lack of both adequate dietitian resources at outpatient centers and comprehensive nutrition guidelines in cancer care. At a large community practice with 210 locations across Texas and Oklahoma, a survey was developed and administered to assess nutrition practices. Methods: Clinic directors in the practice completed a survey to assess for the presence or absence of a malnutrition screen; how nutrition concerns are addressed; and the availability of a dietitian. Results: A total of 26 responses detailed the nutrition processes at 50 unique locations. At 37 (74%) locations, a malnutrition screening tool was utilized and of these, 30 (81%) locations reported utilizing the Malnutrition Screening Tool (MST), a brief, validated tool for outpatient settings including oncology. Seven (19%) sites did not specify what tool was used. Of the clinics that reported completing a malnutrition screen for patients, the screen was completed by the advanced practice provider (APP)/physician in 18 (49%) clinics, a nurse in 4 (11%) clinics, a dietitian in 4 (11%) clinics and a medical assistant in 1 (3%) clinic. At 10 sites more than one provider type was responsible for completing the screen. Nutrition issues were addressed by physicians, APPs, and nurses in 15 (50%), 35 (70%), and 9 (14%) sites respectively (see table). Twenty-two locations (44%) reported referring patients to a dietitian and 10 sites (20%) had a dietitian available in clinic. Forty-one (82%) clinics employed more than one method for addressing nutrition issues. Sixteen of 26 respondents (62%) reported that increased dietitian access would be helpful; this included respondents whose locations already had a dietitian available. Conclusions: Overall, 74% of reporting locations used a malnutrition screening tool and 20% had access to a dietitian on site. Forty-four percent of sites referred to a dietitian if there was a need. This indicates that multiple providers are involved in the nutritional care of oncology patients. In response to these findings, the multidisciplinary PECAN Taskforce was created to develop comprehensive malnutrition screening, implement a referral process for all at-risk patients, enhance nutrition education, and expand dietitian services. Further study will measure the impact of expanded nutrition access on patient outcomes.[Table: see text]