Educators often need help to design courses that lead to transformative learning. This paper outlines a practical approach to course design drawing on the scholarship of teaching and learning, the Association of American Colleges & Universities, and current work in the field. Starting with relevant and urgent student learning outcomes (such as biblical literacy and spiritual quest), effective courses build a series of learning opportunities that enable students to discover content, construct meaning, and create something new. By engaging in the Bible with, in, and alongside of popular culture, students learn more about the Bible, culture, and the relationship between the two. The context of a meta-question requires them to reflect on such essential human concerns as the nature of authority, the construction of identity, and the contextualization of truth. In this way, learning becomes transformative.