Acoustic Features of Oral Reading Prosody and the Relation With Reading Fluency and Reading Comprehension in Taiwanese Children

Purpose: The study aimed to examine whether oral reading prosody—the use of acoustic features (e.g., pitch and duration variations) when reading passages aloud—predicts reading fluency and comprehension abilities. Method: We measured vocabulary, syntax, word reading, reading fluency (including rate and accuracy), reading comprehension (in Grades 3 and 4), and oral reading prosody in Taiwanese third-grade children ( N = 109). In the oral reading prosody task, children were asked to read aloud a passage designed for third graders and then to answer forced-choice questions. Their oral reading prosody was measured through acoustic analyses including the number of pause intrusions, intersentential pause duration, phrase-final comma pause duration, child–adult pitch match, and sentence-final pitch change. Results: Analyses of variance revealed that children's number of pause intrusions differed as a function of word reading. After controlling for age, vocabulary and syntactic knowledge, and word reading, we found that different dimensions of oral reading prosody contributed to reading rate. In contrast, the number of pause intrusions, phrase-final comma pause duration, and child–adult pitch match predicted reading accuracy and comprehension. Conclusions: Oral reading prosody plays an important role in children's reading fluency and reading comprehension in tone languages like Mandarin. Specifically, children need to read texts prosodically as evidenced by fewer pause intrusions, shorter phrase-final comma pause duration, and closer child–adult pitch match, which are early predictive makers of reading fluency and comprehension.

Effects of Bolus Holding on Respiratory–Swallow Coordination in Parkinson's Disease

Purpose: The aim of this study was to examine the effects of bolus holding on respiratory–swallow coordination (RSC) in people with Parkinson's disease (PD). Method: People with PD were prospectively recruited to undergo RSC assessment using simultaneous respiratory inductive plethysmography and flexible laryngoscopy. During RSC assessment, participants swallowed 5-ml thin liquid boluses during held and nonheld swallowing tasks. Measures of RSC were analyzed for each swallow, which included respiratory pause duration, lung volume at swallow initiation, respiratory phase patterning, and the presence of paradoxical respiratory movements. Multilevel statistical modeling was used to determine if differences in RSC were present between the held and nonheld tasks. Results: Thirty-three participants were enrolled. When compared to the nonheld swallows, the held swallows exhibited shorter respiratory pauses ( p = .001, R 2 = .019), lower lung volumes at swallow initiation ( p < .001, R 2 = .116), more frequent exhale–swallow–exhale patterns ( p < .001, OR = 4.30), and less frequent paradoxical respiratory movements ( p = .001, OR = 0.43). Conclusions: Findings from this study revealed that bolus holding significantly influences RSC in people with PD. This demonstrates that bolus holding may be an efficacious strategy to immediately improve RSC in PD. However, clinicians and researchers should consider avoiding bolus holding during swallowing evaluations if attempting to assess RSC behaviors that are most typical for the examinee.

A systematic review and Bayesian meta-analysis of the development of turn taking in adult-child vocal interactions

Background: Turn taking appears to be an almost universal phenomenon in communicative behavior and requires tight coordination between interlocutors. However, there is no current consensus on how and when infants develop the ability to take turns in vocal interactions and which mechanisms are involved. Aim: The current study aims at better understanding the current state of research on the development of turn-taking behaviors in human infants. In particular, we want to map the developmental trajectory of turn-taking abilities and identify key moderators affecting them.Method: We performed a systematic review and Bayesian multilevel meta-analysis of studies reporting response latencies in infant-adult dyadic interactions.Results: We found a poorly connected field (low rate of citations between papers), from which we identified 26 studies and 78 unique estimates of infant response latency. Infants display fast response latencies at an early point in development, which gradually increase up to 40 months. Infants’ responses also appear to be strongly related to the pause duration of their adult conversational partners, and are slower in groups with atypical development.Conclusions: We identify current pitfalls and new directions of research. Specifically, we advocate for the development of shared longitudinal cross-linguistic corpora with turn-by-turn data and rich assessment of the infants' linguistic and social development. We also recommend more explicit definition and testing of computational models of the mechanisms underlying turn-taking.

Fouling Mitigation by Optimizing Flow Rate and Pulsed Electric Field during Bipolar Membrane Electroacidification of Caseinate Solution

The efficiency of separation processes using ion exchange membranes (IEMs), especially in the food industry, is significantly limited by the fouling phenomenon, which is the process of the attachment and growth of certain species on the surface and inside the membrane. Pulsed electric field (PEF) mode, which consists in the application of constant current density pulses during a fixed time (Ton) alternated with pause lapses (Toff), has a positive antifouling impact. The aim of this study was to investigate the combined effect of three different relatively high flow rates of feed solution (corresponding to Reynolds numbers of 187, 374 and 560) and various pulse–pause ratios of PEF current regime on protein fouling kinetics during electrodialysis with bipolar membranes (EDBM) of a model caseinate solution. Four different pulse/pause regimes (with Ton/Toff ratios equal to 10 s/10 s, 10 s/20 s, 10 s/33 s and 10 s/50 s) during electrodialysis (ED) treatment were evaluated at a current density of 5 mA/cm2. It was found that increasing the pause duration and caseinate solution flow rate had a positive impact on the minimization of protein fouling occurring on the cationic surface of the bipolar membrane (BPM) during the EDBM. Both a long pause and high flow rate contribute to a more effective decrease in the concentration of protons and caseinate anions at the BPM surface: a very good membrane performance was achieved with 50 s of pause duration of PEF and a flow rate corresponding to Re = 374. A further increase in PEF pause duration (above 50 s) or flow rate (above Re = 374) did not lead to a significant decrease in the amount of fouling.

Battery Charger with Bidirectional Power Transmission

The gradual reduction in price of electric batteries contributes to their wider use in autonomous and centralized power supply systems as a backup source of electricity and increase the share of electric vehicles. In the paper the conditions for increasing the efficiency of electric vehicle batteries, in particular in the framework of the concept of V2G (Vehicle to Grid) as a drive for the organization of autonomous power supply systems are analyzed. It is shown that this is possible only with the simple integration of batteries into the system, flexibility, and a wide range of modes that have to be provided by unified charge-discharge devices. Such charging devices have to have such features: a wide range of input and output voltage parameters; correction of the input power factor; the ability to take the maximum power from renewable energy sources; high energy efficiency. A review of possible topologies for a charger with bidirectional power transmission and a bridge converter with soft switching of transistors at zero voltage, which has a high efficiency, galvanic isolation and the ability to correct the shape of the current. The modes of operation of the converter are analyzed and conditions of soft switching is obtained. It is shown that soft switching is valid for current that is not less than minimal one. Efficiency of the converter with soft commutation is compared with a similar converter with rigid commutation of transistors. It is shown that static losses in converter with soft commutation it higher than in the rigid one. So, the proposed converter should be used if the increase in static losses is compensated by the lack of dynamic losses. Additional feature of the converter is that the regulation of the output voltage of the converter with soft switching is carried out according to the law of frequency-pulse modulation with a constant pause duration, where the pause duration is determined by the period of resonant processes of the converter. The model of the converter in Matlab Simulink is built and it is shown that the efficiency of the proposed converter topology is 10-15% higher, which together with the possibility of sinusoidal current with THD ≈ 20% and two-way transmission energy indicates the feasibility of its use as a charger for electric vehicles under the concept of V2G. However, it should be noted that the use of LCL filter creates a phase shift between voltage and current and degrades the THD value. To improve the shape, it is possible to use specialized laws of modulation [or to use modular converters, which allow to obtain a continuous current shape and reduce the volume of the filter.

Association between acoustic speech features and non-severe levels of anxiety and depression symptoms across lifespan

Background Several studies have investigated the acoustic effects of diagnosed anxiety and depression. Anxiety and depression are not characteristics of the typical aging process, but minimal or mild symptoms can appear and evolve with age. However, the knowledge about the association between speech and anxiety or depression is scarce for minimal/mild symptoms, typical of healthy aging. As longevity and aging are still a new phenomenon worldwide, posing also several clinical challenges, it is important to improve our understanding of non-severe mood symptoms’ impact on acoustic features across lifetime. The purpose of this study was to determine if variations in acoustic measures of voice are associated with non-severe anxiety or depression symptoms in adult population across lifetime. Methods Two different speech tasks (reading vowels in disyllabic words and describing a picture) were produced by 112 individuals aged 35-97. To assess anxiety and depression symptoms, the Hospital Anxiety Depression Scale (HADS) was used. The association between the segmental and suprasegmental acoustic parameters and HADS scores were analyzed using the linear multiple regression technique. Results The number of participants with presence of anxiety or depression symptoms is low (>7: 26.8% and 10.7%, respectively) and non-severe (HADS-A: 5.4 ± 2.9 and HADS-D: 4.2 ± 2.7, respectively). Adults with higher anxiety symptoms did not present significant relationships associated with the acoustic parameters studied. Adults with increased depressive symptoms presented higher vowel duration, longer total pause duration and short total speech duration. Finally, age presented a positive and significant effect only for depressive symptoms, showing that older participants tend to have more depressive symptoms. Conclusions Non-severe depression symptoms can be related to some acoustic parameters and age. Depression symptoms can be explained by acoustic parameters even among individuals without severe symptom levels.

Transcription elongation through lac repressor-mediated DNA loops

During elongation, RNA polymerase (RNAP) must navigate through proteins that decorate genomic DNA. Several of these mediate long-distance interactions via structures, such as loops, that alter DNA topology and create torsional barriers. We used the tethered particle motion (TPM) technique and magnetic tweezers to monitor transcription of DNA templates in the presence of the lac repressor (LacI) protein which could bind at two sites, one proximal to, and one distal from, the promoter. The bivalent LacI tetramer binds recognition sites (operators) with up to nanomolar affinity depending on the sequence, and the concentration of LacI was adjusted to promote binding to either one or both operators, so as to produce unlooped or looped DNA. We observed that RNAP pausing before a LacI-securing loop was determined not by the affinity of LacI for the operator, but by the order in which the elongating RNAP encountered these operators. TPM experiments showed that, independent of affinity, LacI bound at the promoter-proximal operator became a stronger roadblock when securing a loop. In contrast, LacI bound to the distal operator was a weaker roadblock in a looped configuration suggesting that RNAP might more easily displace LacI obstacles within a torsion-constrained DNA loop. Since protein junctions can efficiently block the diffusion of DNA supercoiling, these data indicate that the positive supercoiling generated ahead of a transcribing RNAP may facilitate the dissociation of a roadblock. In support of this idea, magnetic tweezers measurements indicated that pauses are shorter when RNAP encounters obstacles on positively supercoiled than on relaxed DNA. Furthermore, at similar winding levels of the DNA template, RNAP pause duration decreased with tension. These findings are significant for our understanding of transcription within the crowded and tensed nucleoid.

Effects of Mouthpiece Noninvasive Ventilation on Speech in Men With Muscular Dystrophy: A Pilot Study

Purpose The use of noninvasive ventilation (NIV) is on the rise as an alternative to tracheostomy for individuals with neuromuscular disorders with life-prolonging and quality-of-life benefits. This pilot study was designed to determine if mouthpiece NIV (M-NIV) alters speech in individuals with muscular dystrophy (MD). Method Eight men (23–44 years), seven with Duchenne MD and one with Becker MD, who used daytime M-NIV, were asked to sustain phonation, count, and read under three conditions: (a) Uncued (no instructions), (b) With M-NIV (cued to use M-NIV with all speaking breaths), and (c) Without M-NIV (as tolerated). Breath group and inspiratory durations, syllables/breath group, and relative sound pressure level were determined from audio and video recordings. Results Uncued condition: Participants used the ventilator for all inspirations that preceded sustained phonation and counting. During reading, four participants used M-NIV for all inspirations, one never used it, and three used it for some (19%–41%) inspirations. With- versus Without-M-NIV conditions: Breath group duration was significantly longer across all tasks, syllables per breath group were significantly greater during reading, and inspiratory pause duration during reading was significantly longer with M-NIV than without. Sound pressure level was significantly higher during the first second of sustained phonation with M-NIV (though not for counting and reading). Two participants were unable to complete the reading task audibly without using their M-NIV. Conclusions Speech may be better with M-NIV than without because it is possible to produce longer breath groups and some people with severe respiratory muscle weakness may not be able to speak at all without ventilator-supplied air. Nevertheless, the longer inspiratory pauses that accompany M-NIV may interrupt the flow of speech. Future research is needed to determine the most effective way to use M-NIV for speaking and whether training participants in its use can bring even greater speech benefits.