The role of the myofibroblast in Dupuytren's contracture

1980 ◽  
Vol 116 (7) ◽  
pp. 807-811 ◽  
Author(s):  
W. D. James
Keyword(s):  
Dupuytren’S Contracture ◽  
Dupuytren's Contracture

An Investigation into the Role of Inflammatory Cells in Dupuytren’s Disease

1991 ◽  
Vol 16 (3) ◽  
pp. 267-271 ◽  
Author(s):  
J. G. ANDREW ◽  
S. M. ANDREW ◽  
A. ASH ◽  
B. TURNER
Keyword(s):  
Inflammatory Cells ◽  
Dupuytren’S Disease ◽  
Dupuytren’S Contracture ◽  
Palmar Fascia ◽  
Dupuytren's Disease ◽  
Dupuytren's Contracture ◽  
Microvascular Changes ◽  
Macrophage Marker ◽  
Fibrotic Diseases

An immunohistochemical study was performed on nodules excised from the palmar fascia of patients with Dupuytren’s contracture. In cellular nodules, antibodies to actin (used as a marker for myofibroblasts), desmin, vimentin, Mac 387 (a macrophage marker) and leucocyte common antigen were used. A correlation was demonstrated between the numbers of macrophages and the presence of myofibroblasts. The presence of myofibroblasts is generally considered to indicate the active stage of the disease. Inflammatory cells other than macrophages were largely absent from the nodules, although lymphocytes were frequent in the tissue around the nodules. Microvascular changes were prominent in the nodules and pericyte proliferation was observed around occluded capillaries. Release of growth factors from macrophages may be important in Dupuytren’s contracture, as is the case in other fibrotic diseases. The possible role of macrophages in the aetiology of Dupuytren’s disease is discussed.

Dupuytren's Contracture—The Role of Fasciotomy

HAND ◽  
1983 ◽  
Vol os-15 (2) ◽  
pp. 162-166 ◽  
Author(s):  
J. Colville
Keyword(s):  
Operative Technique ◽  
Dupuytren’S Contracture ◽  
Dupuytren's Contracture

This paper summarises the results obtained in 95 patients treated by fasciotomy, defines the indications for this procedure and describes the operative technique. During a period of seven years a total of 95 patients with 137 fingers affected by Dupuytren's Contracture have been treated by fasciotomy. The minimum follow-up is two years. The oldest patient was 79 years and no patient younger that 50 years was accepted for this form of treatment.

Possible role of plasminogen activator content of the palmar nodules in recurrence of Dupuytren's contracture

1987 ◽  
Vol 12 (6) ◽  
pp. 1017-1019 ◽  
Author(s):  
Giovanni Merlo ◽  
Gian Paolo Ambroggio ◽  
Aldo Mosca ◽  
Elisa Oberto
Keyword(s):  
Plasminogen Activator ◽  
Dupuytren’S Contracture ◽  
Dupuytren's Contracture

Assessment of Percutaneous Fasciotomy in the Management of Dupuytren’s Contracture

1984 ◽  
Vol 9 (2) ◽  
pp. 163-164 ◽  
Author(s):  
D. I. ROWLEY ◽  
M. COUCH ◽  
R. B. CHESNEY ◽  
S. H. NORRIS
Keyword(s):  
Prospective Study ◽  
Metacarpophalangeal Joint ◽  
Dupuytren’S Contracture ◽  
Dupuytren's Contracture

This prospective study of the treatment of Dupuytren’s Contracture in 78 hands has been designed to investigate the role of subcutaneous fasciotomy. The results suggest that in hands where the contracture is predominantly at the metacarpophalangeal joint, then percutaneous fasciotomy is of value.

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