Abscopal Effect in a Patient With Metastatic Merkel Cell Carcinoma Following Radiation Therapy: Potential Role of Induced Antitumor Immunity

2011 ◽  
Vol 147 (7) ◽  
pp. 870 ◽  
Author(s):  
Shane E. Cotter
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Antitumor Immunity ◽  
Potential Role ◽  
Abscopal Effect ◽  
Merkel Cell

The essential role of radiation therapy in securing locoregional control of merkel cell carcinoma

1990 ◽  
Vol 19 (3) ◽  
pp. 583-591 ◽  
Author(s):  
William H. Morrison ◽  
Lester J. Peters ◽  
Elvio G. Silva ◽  
Charles D. Wendt ◽  
K.Kian Ang ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Essential Role ◽  
Locoregional Control ◽  
Merkel Cell

Merkel Cell Carcinoma: The Role of Radiation Therapy in General Management

1999 ◽  
Vol 175 (12) ◽  
pp. 611-615 ◽  
Author(s):  
Marc Bischof ◽  
Michael van Kampen ◽  
Peter Huber ◽  
Michael Wannenmacher
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell ◽  
General Management

scholarly journals The role of radiation therapy and chemotherapy in the treatment of merkel cell carcinoma

Cancer ◽  
1997 ◽  
Vol 80 (5) ◽  
pp. 881-885 ◽  
Author(s):  
Eyal Fenig ◽  
Baruch Brenner ◽  
Alan Katz ◽  
Erica Rakovsky ◽  
Micha Bar Hana ◽  
...  
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Merkel Cell Carcinoma ◽  
Merkel Cell

Adjuvant Radiation Therapy Is Associated With Improved Survival in Merkel Cell Carcinoma of the Skin

2007 ◽  
Vol 25 (9) ◽  
pp. 1043-1047 ◽  
Author(s):  
Pablo Mojica ◽  
David Smith ◽  
Joshua D.I. Ellenhorn
Keyword(s):  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Median Survival ◽  
Merkel Cell Carcinoma ◽  
Adjuvant Radiation ◽  
Merkel Cell ◽  
Adjuvant Radiation Therapy ◽  
Entire Cohort

Purpose Merkel cell carcinoma (MCC) is a rare cutaneous malignancy. Because of the absence of randomized studies, the real benefit of adjuvant radiation therapy in MCC is unclear. The aim of this study was to better define the role of adjuvant radiation therapy in the management of MCC. Methods The Surveillance, Epidemiology, and End Results (SEER) survey from the National Cancer Institute was queried from 1973 through 2002. Retrospective analysis was performed. The end point of the study was overall survival. Results There were 1,665 cases of MCC in the SEER registry. Presentation by stage were 55% stage I, 31% stage II, and 6% stage III. Eight percent of the cases could not be staged because of incomplete data. Surgical intervention was a component of therapy in 89% of the cases (n = 1,487). The median survival for the entire cohort was 49 months, and median follow-up was 40 months. Adjuvant radiation was a component of therapy in 40% of the surgical cases. The median survival for those patients receiving adjuvant radiation therapy was 63 months compared with 45 months for those treated without adjuvant radiation. The use of radiation was associated with an improved survival for patients with all sizes of tumors, but the improvement with radiation use was particularly prominent when analyzing those patients with primary lesions larger than 2 cm. Conclusion The use of adjuvant radiation therapy is associated with improved survival in patients with MCC. Prospective evaluation of adjuvant radiation therapy in this setting is warranted.

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