A Deep Learning Approach for Basal Cell Carcinomas and Bowen’s Disease Recognition in Dermatopathology Image

Basal cell carcinomas and Bowen’s disease (squamous cell carcinoma in situ) are the most common cutaneous tumors. The early diagnoses of these diseases are very important due to their better prognosis. But it is a heavy workload for the pathologists to recognize a large number of pathological images and diagnose these diseases. So, there is an urgent need to develop an automatic method for detecting and classifying the skin cancers. This paper presents a recognition system of dermatopathology images based on the deep convolutional neural networks (CNN). The dermatopathology images are collected from the hospital. The deep learning model is trained using different image datasets. It can be found that the recognition accuracy of the system can be improved by using data augmentation even if the number of the clinical samples are not increased. But the recognition accuracy of the system is the highest when the number of the original histological image is increased. The experimental results that the system can correctly recognize 88.5% of patients with basal cell carcinoma and 86.5% of patients with Bowen’s disease.

Extracellular Vesicles from Esophageal Squamous Cell Carcinoma Promote Angiogenesis and Tumor Growth

Angiogenesis is a prerequisite for tumor development and metastasis. Emerging evidence shows that tumor-derived extracellular vesicles (EVs) are an important component of tumor microenvironment, which participate in the communication between normal cells and tumor cells. In this study, we aimed to investigate the role of EVs derived from esophageal squamous cell carcinoma (ESCC) on tumor angiogenesis. We found that ESCC cell-derived EVs promoted the proliferation, migration, and tubule formation of human umbilical vein endothelial cells in vitro, and enhanced angiogenesis and tumor growth in vivo. Our results suggest that ESCC cell-derived EVs could promote angio-genesis and tumor growth, which also indicated the application of EVs as a valuable therapeutic strategy of ESCC.