Asymmetric Synthesis of Chiral Sulfoxides

2009 ◽  
pp. 1-29 ◽  
Author(s):  
Henri B. Kagan
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Sulfoxides

Asymmetric synthesis of both enantiomers of 2.5-hexane diol and 2.6-heptane diol induced by chiral sulfoxides

1994 ◽  
Vol 35 (29) ◽  
pp. 5297-5300 ◽  
Author(s):  
Guy Solladié ◽  
Nathalie Huser ◽  
José Luis Garcia-Ruano ◽  
Javier Adrio ◽  
M.Carmen Carreño ◽  
...  
Keyword(s):  
Asymmetric Synthesis ◽  
Chiral Sulfoxides

scholarly journals Isolation of Rhodococcus sp. Strain ECU0066, a New Sulfide Monooxygenase-Producing Strain for Asymmetric Sulfoxidation

2008 ◽  
Vol 75 (2) ◽  
pp. 551-556 ◽  
Author(s):  
Ai-Tao Li ◽  
Jian-Dong Zhang ◽  
Jian-He Xu ◽  
Wen-Ya Lu ◽  
Guo-Qiang Lin
Keyword(s):  
Enzyme Activity ◽  
Asymmetric Synthesis ◽  
Bacterial Strain ◽  
Enantiomeric Excess ◽  
Good Activity ◽  
Rich Medium ◽  
Practical Application ◽  
Chiral Sulfoxides ◽  
Good Potential ◽  
Rhodococcus Sp

ABSTRACT A new and efficient sulfide monooxygenase-producing strain, ECU0066, was isolated and identified as a Rhodococcus sp. that could transform phenylmethyl sulfide (PMS) to (S)-sulfoxide with 99% enantiomeric excess via two steps of enantioselective oxidations. Its enzyme activity could be effectively induced by adding PMS or phenylmethyl sulfoxide (PMSO) directly to a rich medium at the early log phase (6 h) of fermentation, resulting in over 10-times-higher production of the enzyme. This bacterial strain also displayed fairly good activity and enantioselectivity toward seven other sulfides, indicating a good potential for practical application in asymmetric synthesis of chiral sulfoxides.

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