Obtaining the kinetic function of depolymerization from evolving molecular weight distribution data-an inverse problem

AIChE Journal ◽  
2012 ◽  
Vol 59 (3) ◽  
pp. 912-922 ◽  
Author(s):  
Y. Leong Yeow ◽  
Bifei Guan ◽  
Liang Wu ◽  
Tze-Ming Yap ◽  
Jong-Leng Liow ◽  
...  
Keyword(s):  
Molecular Weight ◽  
Inverse Problem ◽  
Molecular Weight Distribution ◽  
Weight Distribution ◽  
Distribution Data ◽  
Kinetic Function

scholarly journals Molecular Weight Distribution Studies on Heparin

1977 ◽  
Author(s):  
Grant H. Barlow
Keyword(s):  
Molecular Weight ◽  
Molecular Weight Distribution ◽  
Weight Distribution ◽  
Gel Filtration ◽  
Equilibrium Analysis ◽  
Resolving Power ◽  
Sedimentation Equilibrium ◽  
Distribution Data ◽  
Molecular Weights ◽  
Distribution Studies

The determination of molecular weight distribution using the sedimentation equilibrium analysis developed for polymers by T. Scholte (J. Polymer Sei, 6, 111, 1968) has been adapted for heparin analysis. Pork mucosal heparin separated into molecular weight subfractions by gel filtration on Ultrogel AcA44 (L.K.B.) was used to test the validity and resolving power of the method. Results indicate that the method is able to differentiate molecular weight distribution satisfactorily. Comparisons have been made of molecular weight distribution of samples from different species, organs and manufacturers. Average molecular weights for most samples center around 15,000 Dal tons, but samples show considerable variation in their distribution data. Results suggest that variations between manufacturers is more pronounced than the specie and organ difference indicating the importance of the purification procedure.

scholarly journals The molecular-weight distribution of glycosaminoglycans

1973 ◽  
Vol 135 (4) ◽  
pp. 631-637 ◽  
Author(s):  
John J. Hopwood ◽  
H. Clem Robinson
Keyword(s):  
Molecular Weight ◽  
Molecular Weight Distribution ◽  
Weight Distribution ◽  
Chondroitin Sulphate ◽  
Average Molecular Weight ◽  
Length Distribution ◽  
Accurate Estimation ◽  
Distribution Data ◽  
Gel Chromatography ◽  
Chain Length Distribution

1. A rapid and sensitive method for the accurate estimation of the molecular-weight distribution of keratan sulphate and chondroitin sulphate isolated from adult bovine nasal septum and intervertebral disc is described. The method utilizes gel chromatography of reductively labelled glycosaminoglycan and end-group estimation of number-average molecular weight for each fraction across the peak of eluted glycosaminoglycan. 2. Chain-length distribution data obtained by this procedure are used to evaluate mechanisms of chondroitin sulphate biosynthesis.

Sign in / Sign up

Export Citation Format

Share Document