Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Andrea Defant; Ines Mancini; Rossella Tomazzolli; Jan Balzarini

doi:10.1002/ardp.201400235

Design, Synthesis, and Biological Evaluation of Novel 2H-Pyran-2-one Derivatives as Potential HIV-1 Reverse Transcriptase Inhibitors

Archiv der Pharmazie ◽

10.1002/ardp.201400235 ◽

2014 ◽

Vol 348 (1) ◽

pp. 23-33 ◽

Cited By ~ 11

Author(s):

Andrea Defant ◽

Ines Mancini ◽

Rossella Tomazzolli ◽

Jan Balzarini

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Arylazolylthioacetanilide. Part 11: Design, Synthesis and Biological Evaluation of 1,2,4-triazole Thioacetanilide Derivatives as Novel Non-nucleoside HIV-1 Reverse Transcriptase Inhibitors

Medicinal Chemistry ◽

10.2174/1573406411309070010 ◽

2013 ◽

Vol 9 (7) ◽

pp. 968-973 ◽

Cited By ~ 9

Author(s):

Zhenyu Li ◽

Yuan Cao ◽

Peng Zhan ◽

Christophe Pannecouque ◽

Jan Balzarini ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis, and biological evaluation of novel 5-Alkyl-6-Adamantylmethylpyrimidin-4(3H)-ones as HIV-1 non-nucleoside reverse-transcriptase inhibitors

Chemical Biology & Drug Design ◽

10.1111/cbdd.12765 ◽

2016 ◽

Vol 88 (3) ◽

pp. 380-385 ◽

Cited By ~ 2

Author(s):

Wenxin Li ◽

Boshi Huang ◽

Dongwei Kang ◽

Erik De Clercq ◽

Dirk Daelemans ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Newer aminopyrimidinimino isatin analogues as non-nucleoside HIV-1 reverse transcriptase inhibitors for HIV and other opportunistic infections of AIDS: design, synthesis and biological evaluation

Il Farmaco ◽

10.1016/j.farmac.2005.03.005 ◽

2005 ◽

Vol 60 (5) ◽

pp. 377-384 ◽

Cited By ~ 27

Author(s):

D. Sriram ◽

T.R. Bal ◽

P. Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Opportunistic Infections ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, Synthesis, and Biological Evaluation of 1-[(2-Benzyloxyl/alkoxyl)methyl]-5-halo-6-aryluracils as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with an Improved Drug Resistance Profile

Journal of Medicinal Chemistry ◽

10.1021/jm201506e ◽

2012 ◽

Vol 55 (5) ◽

pp. 2242-2250 ◽

Cited By ~ 26

Author(s):

Xiaowei Wang ◽

Jianfang Zhang ◽

Yang Huang ◽

Ruiping Wang ◽

Liang Zhang ◽

...

Keyword(s):

Drug Resistance ◽

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Resistance Profile ◽

Drug Resistance Profile ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Newer Aminopyrimidinimino Isatin Analogues as Non-Nucleoside HIV-1 Reverse Transcriptase Inhibitors for HIV and Other Opportunistic Infections of AIDS: Design, Synthesis and Biological Evaluation.

ChemInform ◽

10.1002/chin.200539145 ◽

2005 ◽

Vol 36 (39) ◽

Author(s):

D. Sriram ◽

T. R. Bal ◽

P. Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Opportunistic Infections ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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ChemInform Abstract: Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones (I): HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations.

ChemInform ◽

10.1002/chin.200030099 ◽

2010 ◽

Vol 31 (30) ◽

pp. no-no

Author(s):

Marino Artico ◽

et al. et al.

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Abstract Structure ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2013.04.052 ◽

2013 ◽

Vol 65 ◽

pp. 134-143 ◽

Cited By ~ 16

Author(s):

Shiqiong Yang ◽

Christophe Pannecouque ◽

Dirk Daelemans ◽

Xiao-Dong Ma ◽

Yang Liu ◽

...

Keyword(s):

Reverse Transcriptase ◽

Molecular Design ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones: HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations

Journal of Medicinal Chemistry ◽

10.1021/jm9901125 ◽

2000 ◽

Vol 43 (9) ◽

pp. 1886-1891 ◽

Cited By ~ 80

Author(s):

Marino Artico ◽

Romano Silvestri ◽

Eugenia Pagnozzi ◽

Biancamaria Bruno ◽

Ettore Novellino ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Nucleoside Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis, and biological evaluation of new 3-hydroxy-2-oxo-3-trifluoromethylindole as potential HIV-1 reverse transcriptase inhibitors

Medicinal Chemistry Research ◽

10.1007/s00044-007-9004-0 ◽

2007 ◽

Vol 15 (9) ◽

pp. 492-510 ◽

Cited By ~ 16

Author(s):

Núbia Boechat ◽

Warner B. Kover ◽

Mônica M. Bastos ◽

Nelilma C. Romeiro ◽

Alessa S. C. Silva ◽

...

Keyword(s):

Reverse Transcriptase ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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Design, synthesis and biological evaluation of novel non-nucleoside HIV-1 reverse transcriptase inhibitors with broad-spectrum chemotherapeutic properties

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2004.08.028 ◽

2004 ◽

Vol 12 (22) ◽

pp. 5865-5873 ◽

Cited By ~ 40

Author(s):

Dharmarajan Sriram ◽

Tanushree Ratan Bal ◽

Perumal Yogeeswari

Keyword(s):

Reverse Transcriptase ◽

Broad Spectrum ◽

Biological Evaluation ◽

Reverse Transcriptase Inhibitors ◽

Design Synthesis ◽

Synthesis And Biological Evaluation ◽

Hiv 1

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