José Agustín Quincoces Suárez
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Alfredo Peña Ricardo
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José Matheus Freitas Costa
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Carolina Passarelli Gonçalves
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Mário Augusto Tremante
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...
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Some thiophenic derivatives show important biological activity or are used as intermediates in organic synthesis.
For this reason, it is very important to develop new synthesis procedures with good yields and using few synthesis steps.
The present work offers an over-view of the method for obtaining substituted thiophenes reported in the literature, and the
synthetic procedures used from push-pull systems. In this work, we present the synthesis of 14 new tetrasubstituted
thiophenes starting from amino mercaptoacrylates and a-brominated acetamides, derived from furoyl and
benzoylacetonitrile, respectively. Best yields (66 to 85%) were obtained through ultrasonic irradiation. Combined use of
spectroscopic methods and elementary analysis was used for characterization of all the compounds.
