ChemInform Abstract: Use of an Allylic Anchor Group and of Its Palladium-Catalyzed Hydrostannolytic Cleavage in the Solid Phase Synthesis of Protected Peptide Fragments.

ChemInform ◽  
1989 ◽  
Vol 20 (52) ◽  
Author(s):  
F. GUIBE ◽  
O. DANGLES ◽  
G. BALAVOINE ◽  
A. LOFFET
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Peptide Fragments ◽  
Phase Synthesis ◽  
Anchor Group ◽  
Palladium Catalyzed

Solid Phase Synthesis of a Somatostatin Amide Analogue Using Acid Labile t-Bumeoc Protection and an Acid Labile Anchor Group

1992 ◽  
Vol 57 (8) ◽  
pp. 1707-1718
Author(s):  
Wolfgang Voelter ◽  
Gerhard Breipohl ◽  
Chryssa Tzougraki ◽  
Eveline Jungfleisch-Turgut
Keyword(s):  
Amino Acids ◽  
Acetic Acid ◽  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Somatostatin Analogue ◽  
Phase Synthesis ◽  
Anchor Group ◽  
Amide Form ◽  
Polystyrene Resin ◽  
Acid Labile

The solid phase synthesis of an amidated somatostatin analogue based on the principle of differentiated acidolysis is described. The acid labile and smoothly cleavable t-Bumeoc moiety (1% TFA/DCM) is used for temporary Nα-protection of D- and L-amino acids and [4-[[[9H-fluoren-9-yl-methoxycarbonyl]amino](4-methoxyphenyl)methyl]-2-methylphenoxy]acetic acid, attached to an aminomethylated polystyrene resin is used as acid sensitive linker of the solid carrier which releases the peptide in its amide form by treatment with TFA. Its preparation is described in detail.

Solid-phase synthesis of skeletally diverse benzofused sultams via palladium-catalyzed cyclization

2011 ◽  
Vol 52 (13) ◽  
pp. 1456-1458 ◽  
Author(s):  
Wenteng Chen ◽  
Zhi Li ◽  
Lili Ou ◽  
Marc A. Giulianott ◽  
Richard A. Houghten ◽  
...  
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Palladium Catalyzed

Solid-Phase Synthesis of Indolecarboxylates Using Palladium-Catalyzed Reactions

2003 ◽  
Vol 68 (15) ◽  
pp. 6011-6019 ◽  
Author(s):  
Kazuo Yamazaki ◽  
Yosuke Nakamura ◽  
Yoshinori Kondo
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Palladium Catalyzed ◽  
Catalyzed Reactions

Solid-phase synthesis of indolines via palladium-catalyzed cyclization

2003 ◽  
Vol 44 (12) ◽  
pp. 2569-2572 ◽  
Author(s):  
Yongping Yu ◽  
John M Ostresh ◽  
Richard A Houghten
Keyword(s):  
Solid Phase Synthesis ◽  
Solid Phase ◽  
Phase Synthesis ◽  
Palladium Catalyzed
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