ChemInform Abstract: 1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: Novel Synthesis via Cyclization of N-Acyl-S-methylisothioureas with Alkylhydrazines and Their Potent Corticotropin-Releasing Factor-1 (CRF1) Receptor Antagonist Activities.

Crf1 Receptor ◽

Novel Synthesis ◽

Corrigendum to “1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: Novel synthesis via cyclization of N-acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-releasing factor-1 (CRF1) receptor antagonist activities” [Bioorg. Med. Chem. Lett. 11 (2001) 3165–3168]

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2009.02.124 ◽

2010 ◽

Vol 20 (17) ◽

pp. 5362

Author(s):

Chen Chen ◽

Raymond Dagnino ◽

Charles Q. Huang ◽

James R. McCarthy ◽

Dimitri E. Grigoriadis

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽

Novel Synthesis ◽

1-Alkyl-3-amino-5-aryl-1H-[1,2,4]triazoles: novel synthesis via cyclization of N-Acyl-S-methylisothioureas with alkylhydrazines and their potent corticotropin-Releasing factor-1 (CRF1) receptor antagonist activities

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/s0960-894x(01)00657-6 ◽

2001 ◽

Vol 11 (24) ◽

pp. 3165-3168 ◽

Cited By ~ 33

Author(s):

Chen Chen ◽

Raymond Dagnino ◽

Charles Q. Huang ◽

James R. McCarthy ◽

Dimitri E. Grigoriadis

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽

Novel Synthesis ◽

A Novel Synthesis of a 1,3-Disubstituted 1,3-Dihydro-2H-imidazo[4,5-b]pyridin-2-one. Application to GW808990 a CRF1 Receptor Antagonist

Heterocycles ◽

10.3987/com-10-s(e)62 ◽

2010 ◽

Vol 82 (1) ◽

pp. 297 ◽

Cited By ~ 2

Author(s):

Jerome F. Hayes ◽

Matthew E. Popkin

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽

Novel Synthesis ◽

Discovery of NBI-77860/GSK561679, a potent corticotropin-releasing factor (CRF1) receptor antagonist with improved pharmacokinetic properties

Bioorganic & Medicinal Chemistry Letters ◽

10.1016/j.bmcl.2010.10.095 ◽

2010 ◽

Vol 20 (24) ◽

pp. 7259-7264 ◽

Cited By ~ 25

Author(s):

John E. Tellew ◽

Marion Lanier ◽

Manisha Moorjani ◽

Emily Lin ◽

Zhiyong Luo ◽

...

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽

Crf1 Receptor Antagonist ◽

Pharmacokinetic Properties

R278995/CRA0450, a corticotropin-releasing factor (CRF1) receptor antagonist modulates REM sleep measures in rats: Implication for therapeutic indication

European Journal of Pharmacology ◽

10.1016/j.ejphar.2012.01.023 ◽

2012 ◽

Vol 680 (1-3) ◽

pp. 63-68 ◽

Cited By ~ 3

Author(s):

Abdallah Ahnaou ◽

Thomas Steckler ◽

Annick Heylen ◽

Ludo Kennis ◽

Atsuro Nakazato ◽

...

Keyword(s):

Receptor Antagonist ◽

Rem Sleep ◽

Therapeutic Indication ◽

Crf1 Receptor ◽

ChemInform Abstract: Discovery of NBI-77860/GSK561679, a Potent Corticotropin-Releasing Factor (CRF1) Receptor Antagonist with Improved Pharmacokinetic Properties.

ChemInform ◽

10.1002/chin.201115203 ◽

2011 ◽

Vol 42 (15) ◽

pp. no-no

Author(s):

John P. Williams ◽

et al. et al.

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽

Crf1 Receptor Antagonist ◽

Pharmacokinetic Properties

Corticotropin-releasing factor receptor2 (CRF2) agonist and CRF1 receptor antagonist decrease pain response to colorectal distention in rats

Gastroenterology ◽

10.1016/s0016-5085(98)84230-3 ◽

1998 ◽

Vol 114 ◽

pp. A1040 ◽

Cited By ~ 1

Author(s):

M. Million ◽

T. Nozu ◽

A. Gauthier ◽

D. Adelson ◽

C. Maillot ◽

...

Keyword(s):

Receptor Antagonist ◽

Pain Response ◽

Crf1 Receptor ◽

Crf1 Receptor Antagonist ◽

Colorectal Distention

ChemInform Abstract: A Novel Synthesis of a 1,3-Disubstituted 1,3-Dihydro-2H-imidazo[4,5-b]pyridin-2-one. Application to GW808990 a CRF1 Receptor Antagonist.

ChemInform ◽

10.1002/chin.201118146 ◽

2011 ◽

Vol 42 (18) ◽

pp. no-no

Author(s):

Jerome F. Hayes ◽

Matthew E. Popkin

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽

Novel Synthesis ◽

The CRF1 receptor antagonist SSR125543 prevents stress-induced cognitive deficit associated with hippocampal dysfunction: Comparison with paroxetine and d-cycloserine

Psychopharmacology ◽

10.1007/s00213-013-3020-1 ◽

2013 ◽

Vol 228 (1) ◽

pp. 97-107 ◽

Cited By ~ 14

Author(s):

J. Philbert ◽

C. Belzung ◽

G. Griebel

Keyword(s):

Receptor Antagonist ◽

Cognitive Deficit ◽

Crf1 Receptor ◽

Hippocampal Dysfunction ◽

Discovery of 4-chloro-2-(2,4-dichloro-6-methylphenoxy)-1-methyl-7-(pentan-3-yl)-1H-benzimidazole, a novel CRF1 receptor antagonist

Bioorganic & Medicinal Chemistry ◽

10.1016/j.bmc.2016.11.011 ◽

2017 ◽

Vol 25 (5) ◽

pp. 1556-1570 ◽

Cited By ~ 2

Author(s):

Michiyo Mochizuki ◽

Takuto Kojima ◽

Katsumi Kobayashi ◽

Etsuo Kotani ◽

Yuji Ishichi ◽

...

Keyword(s):

Receptor Antagonist ◽

Crf1 Receptor ◽