Impact of cyclofructan derivatives as efficient chiral selector in chiral analysis: An overview

Chirality ◽  
2021 ◽  
Author(s):  
Hassan Y. Aboul‐Enein ◽  
Valliappan Kannappan ◽  
Selvakumar Kanthiah
Keyword(s):  
Chiral Selector ◽  
Chiral Analysis

Removal of Sodium Ion and Chiral Analysis Using Crown Ether as a Chiral Selector in Microchip Electrophoresis

2002 ◽  
pp. 575-577
Author(s):  
Seung Il Cho ◽  
Jiyeon Shim ◽  
Min-Su Kim ◽  
Doo Soo Chung ◽  
Yong-Kweon Kim
Keyword(s):  
Crown Ether ◽  
Microchip Electrophoresis ◽  
Chiral Selector ◽  
Sodium Ion ◽  
Chiral Analysis

scholarly journals The Use of Dual Cyclodextrin Chiral Selector Systems in the Enantioseparation of Pharmaceuticals by Capillary Electrophoresis: An Overview

Molecules ◽  
2021 ◽  
Vol 26 (8) ◽  
pp. 2261
Author(s):  
Gabriel Hancu ◽  
Lajos Attila Papp ◽  
Gergő Tóth ◽  
Hajnal Kelemen
Keyword(s):  
Capillary Electrophoresis ◽  
Efficient Solution ◽  
Chiral Selector ◽  
Chiral Discrimination ◽  
Chiral Analysis ◽  
Chiral Selectors ◽  
Separation Of Enantiomers ◽  
Pharmaceutical Substances ◽  
Current Review ◽  
General Aspects

Cyclodextrin (CD) derivatives are the most efficient and frequently used chiral selectors (CSs) in capillary electrophoresis (CE). There are situations when the use of a single CD as CS is not enough to obtain efficient chiral discrimination of the enantiomers; in these cases, sometimes this problem can be resolved using a dual CD system. The use of dual CD systems can often dramatically enhance enantioseparation selectivity and can be applied for the separation of many analytes of pharmaceutical interest for which enantioseparation by CE with another CS systems can be problematic. Usually in a dual CD system an anionic CD is used together with a neutral one, but there are situations when the use of a cationic CD with a neutral one or the use of two neutral CDs or even two ionized CDs can be an efficient solution. In the current review we present general aspects of the use of dual CD systems in the analysis of pharmaceutical substances. Several examples of applications of the use of dual CD systems in the analysis of pharmaceuticals are selected and discussed. Theoretical aspects regarding the separation of enantiomers through simultaneous interaction with the two CSs are also explained. Finally, advantages, disadvantages, potential and new direction in this chiral analysis field are highlighted.

Chiral analysis by capillary electrophoresis using antibiotics as chiral selector

1998 ◽  
Vol 807 (1) ◽  
pp. 37-56 ◽  
Author(s):  
Claudia Desiderio ◽  
Salvatore Fanali
Keyword(s):  
Capillary Electrophoresis ◽  
Chiral Selector ◽  
Chiral Analysis

CE, with hydroxypropyl-β-cyclodextrin as chiral selector, for separation and determination of the enantiomers of amloclipine in the serum of hypertension patients

2007 ◽  
Vol 65 (9-10) ◽  
pp. 575-579
Author(s):  
R WANG ◽  
Z JIA ◽  
J FAN ◽  
L CHEN ◽  
H XIE ◽  
...  
Keyword(s):  
Chiral Selector

CHIRAL ANALYSIS OF ISOPULEGOL BY FOURIER TRANSFORM MOLECULAR ROTATIONAL SPECTROSCOPY

2016 ◽  
Author(s):  
Luca Evangelisti ◽  
Brooks Pate ◽  
Lorenzo Spada ◽  
Nathan Seifert
Keyword(s):  
Fourier Transform ◽  
Chiral Analysis ◽  
Rotational Spectroscopy

INTERNAL DYNAMICS AND CHIRAL ANALYSIS OF PULEGONE, USING MICROWAVE BROADBAND SPECTROSCOPY

2017 ◽  
Author(s):  
Anna Krin ◽  
Juan Lopez ◽  
Susana Blanco ◽  
Pablo Pinacho ◽  
Juan Avilés-Moreno ◽  
...  
Keyword(s):  
Chiral Analysis ◽  
Internal Dynamics ◽  
Broadband Spectroscopy

Separation of DL-Phenylalanine by Chiral Selector‐Supported Ultrafiltration

2019 ◽  
Vol 6 (1) ◽  
pp. 18-23
Author(s):  
Sema Salgın ◽  
◽  
Seda Öner ◽  
Uğur Salgın
Keyword(s):  
Chiral Selector

scholarly journals Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3527
Author(s):  
Ali Fouad ◽  
Adel A. Marzouk ◽  
Montaser Sh. A. Shaykoon ◽  
Samy M. Ibrahim ◽  
Sobhy M. El-Adl ◽  
...  
Keyword(s):  
Glycidyl Methacrylate ◽  
Chiral Stationary Phase ◽  
Reversed Phase ◽  
Chiral Selector ◽  
Antifungal Drugs ◽  
Organic Polymer ◽  
Rp Hplc ◽  
Macrocyclic Antibiotic ◽  
Adrenergic Blockers ◽  
H1 Blockers

Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.

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