Potential of contrast agents to enhance in vivo confocal microscopy and optical coherence tomography in dermatology: A review

2019 ◽  
Vol 12 (6) ◽  
Author(s):  
Hans C. Ring ◽  
Niels M. Israelsen ◽  
Ole Bang ◽  
Merete Haedersdal ◽  
Mette Mogensen
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Contrast Agents ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy

Characteristics of Linear Interstitial Keratitis by In Vivo Confocal Microscopy and Anterior Segment Optical Coherence Tomography

Cornea ◽  
2018 ◽  
Vol 37 (6) ◽  
pp. 785-788
Author(s):  
Aleksandra Petrovic ◽  
Kattayoon Hashemi ◽  
Frank Blaser ◽  
Wolfgang Wild ◽  
George Kymionis
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Interstitial Keratitis

Clinical and morphological manifestations of aniridia-associated keratopathy on anterior segment optical coherence tomography and in vivo confocal microscopy

2017 ◽  
Vol 15 (4) ◽  
pp. 759-769 ◽  
Author(s):  
Anna Voskresenskaya ◽  
Nadezhda Pozdeyeva ◽  
Tatyana Vasilyeva ◽  
Yevgeniy Batkov ◽  
Aleksandr Shipunov ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy

scholarly journals Examination of corneal deposits in nephropathic cystinosis using in vivo confocal microscopy and anterior segment optical coherence tomography: an age-dependent cross sectional study

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Anita Csorba ◽  
Erika Maka ◽  
Otto Alexander Maneschg ◽  
Attila Szabó ◽  
Nóra Szentmáry ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Anterior Segment ◽  
Interquartile Range ◽  
Nephropathic Cystinosis ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Crystal Deposition ◽  
Crystal Density

Abstract Background Presence of corneal cystine crystals is the main ocular manifestation of cystinosis, although controversial findings concerning the corneal layer with the highest density have been reported. The aim of this study was the analysis of the characteristics of crystal arrangement in different corneal layers and the assessment of corneal morphological changes with age. Methods A cross sectional study was carried out in three children and three adults who had nephropathic cystinosis and corneal cystine depositions. All patients underwent a comprehensive ophthalmological examination including best corrected distance visual acuity, slit-lamp examination, in vivo confocal microscopy and anterior segment optical coherence tomography. An evaluation of the depth of crystal deposits and crystal density in different corneal layers was also performed. Due to the low number of subjects no statistical comparison was performed. Results Anterior segment optical coherence tomography images revealed deposition of hyperreflective crystals from limbus to limbus in each patient. Crystals appeared as randomly oriented hyperreflective, elongated structures on in vivo confocal microscopy images in all corneal layers except the endothelium. In children the deposits occurred predominantly in the anterior stroma, while in adults, the crystals were mostly localized in the posterior corneal stroma with the depth of crystal deposition showing an increasing tendency with age (mean depth of crystal density was 353.17 ± 49.23 μm in children and it was 555.75 ± 25.27 μm in adults). Mean crystal density of the epithelium was 1.47 ± 1.17 (median: 1.5; interquartile range: 0.3–2.4). Mean crystal density of the anterior and posterior stroma of children and adults was 3.37 ± 0.34 (median: 3.4; interquartile range: 3.25–3.55) vs. 1.23 ± 0.23 (median: 1.2; interquartile range: 1.05–1.35) and 0.76 ± 0.49 (median: 0.7; interquartile range: 0.4–1.15) vs. 3.63 ± 0.29 (median: 3.7; interquartile range: 3.45–3.8), respectively. Endothelium had intact structure in all cases. Some hexagonal crystals were observed in two subjects. Conclusions In vivo confocal microscopy and anterior segment optical coherence tomography confirmed an age-related pattern of crystal deposition. In children, crystals tend to locate anteriorly, while in adults, deposits are found posteriorly in corneal stroma.

scholarly journals Morphologic study of the cornea by in vivo confocal microscopy and optical coherence tomography after bifocal refractive corneal inlay implantation

2014 ◽  
Vol 40 (4) ◽  
pp. 545-557 ◽  
Author(s):  
Alex Malandrini ◽  
Gianluca Martone ◽  
Annalisa Canovetti ◽  
Luca Menabuoni ◽  
Angelo Balestrazzi ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Morphologic Study ◽  
Corneal Inlay

Multimodal imaging of pre-Descemet corneal dystrophy

2019 ◽  
Vol 30 (5) ◽  
pp. 908-916 ◽  
Author(s):  
Munirah Alafaleq ◽  
Cristina Georgeon ◽  
Kate Grieve ◽  
Vincent M Borderie
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Multimodal Imaging ◽  
Case Series ◽  
Corneal Dystrophy ◽  
Spectral Domain ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Descemet Membrane

Purpose: The aim of this study was to assess structural and histological changes associated with pre-Descemet corneal dystrophy with multimodal in vivo imaging. Methods: Retrospective case series including eight corneas from four unrelated male patients with pre-Descemet corneal dystrophy characterized by the presence of punctiform gray opacities located just anterior to the Descemet membrane at slit-lamp examination of both eyes. In vivo confocal microscopy images were obtained in the central, paracentral, and peripheral corneal zones from the superficial epithelial cell layer down to the corneal endothelium in both eyes. Spectral domain optical coherence tomography scans (central and limbal zones) and mapping of both corneas were acquired. Results: Diffuse small extracellular stromal deposits, presence of enlarged hyperreflective keratocytes in the posterior stroma with either hyperreflective or hyporeflective intracellular dots, and presence of activated keratocytes in the very anterior stroma were observed in all corneas with in vivo confocal microscopy. Spectral domain optical coherence tomography scans showed a hyperreflective line anterior to Descemet’s membrane running from limbus to limbus and associated with a second thinner hyperreflective line just beneath Bowman’s layer. Fine hyperreflective particles were observed in the posterior, mid, and anterior stroma on optical coherence tomography scans. Conclusion: The clinical presentation and structural anomalies found in isolated sporadic pre-Descemet corneal dystrophy are in favor of a degenerative process affecting corneal keratocytes with no epithelial or endothelial involvement. The maximum damage is found just anterior to the Descemet membrane resulting in pre-Descemet membrane location of stromal opacities. Multimodal imaging of cornea reveals that the disorder affects the whole stroma and it permits better understanding of pre-Descemet corneal dystrophy pathophysiology together with ascertained diagnosis.

scholarly journals Peripheral hypertrophic subepithelial corneal degeneration: clinical aspects related to in vivo confocal microscopy and optical coherence tomography

2019 ◽  
Vol Volume 12 ◽  
pp. 237-241
Author(s):  
Jeanne Martine Gunzinger ◽  
Nafsika Voulgari ◽  
Aleksandra Petrovic ◽  
Kattayoon Hashemi ◽  
Georgios Kymionis
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Clinical Aspects ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy ◽  
Corneal Degeneration

Corneal Remodeling After Myopic SMILE: An Optical Coherence Tomography and In Vivo Confocal Microscopy Study

2020 ◽  
Vol 36 (9) ◽  
pp. 597-605
Author(s):  
Norman Romito ◽  
Liem Trinh ◽  
Isabelle Goemaere ◽  
Vincent Borderie ◽  
Laurent Laroche ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Confocal Microscopy ◽  
Microscopy Study ◽  
Optical Coherence ◽  
In Vivo Confocal Microscopy
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