scholarly journals Regional gene therapy for full-thickness articular cartilage lesions using naked DNA with a collagen matrix

2006 ◽  
Vol 24 (5) ◽  
pp. 1118-1127 ◽  
Author(s):  
Paul E. Di Cesare ◽  
Sally R. Frenkel ◽  
Cathy S. Carlson ◽  
Carrie Fang ◽  
Chuanju Liu
Keyword(s):  
Gene Therapy ◽  
Articular Cartilage ◽  
Collagen Matrix ◽  
Full Thickness ◽  
Cartilage Lesions ◽  
Naked Dna ◽  
Articular Cartilage Lesions ◽  
Regional Gene

Functional Outcome of Knee Articular Cartilage Repair in Adolescent Athletes

2005 ◽  
Vol 33 (8) ◽  
pp. 1147-1153 ◽  
Author(s):  
Kai Mithöfer ◽  
Tom Minas ◽  
Lars Peterson ◽  
Howard Yeon ◽  
Lyle J. Micheli
Keyword(s):  
Articular Cartilage ◽  
Functional Outcome ◽  
Cartilage Repair ◽  
Autologous Chondrocyte Transplantation ◽  
Full Thickness ◽  
Chondrocyte Transplantation ◽  
Adolescent Athletes ◽  
Cartilage Lesions ◽  
Articular Cartilage Lesions ◽  
Autologous Chondrocyte

Background Limited information exists about the treatment of full-thickness articular cartilage lesions of the knee in adolescent athletes. Purpose To evaluate the functional outcome and athletic activity after articular cartilage repair in the knees of adolescent athletes. Study Design Case series; Level of evidence, 4. Methods Twenty adolescent athletes with full-thickness articular cartilage lesions of the knee were treated with autologous chondrocyte transplantation. Functional outcome was evaluated by subjective patient outcome rating, knee activity scores, and level of athletic participation. Results At a mean of 47 months after autologous chondrocyte transplantation, 96% of adolescents reported good or excellent results with significant increases in postoperative Tegner activity scores and Lysholm scores. Ninety-six percent returned to high-impact sports and 60% to an athletic level equal or higher than that before knee injury. Return to preinjury sports correlated with shorter preoperative symptoms and a lower number of prior operations. All adolescents with preoperative symptoms ≤12 months returned to preinjury-level athletics, compared to 33% with preoperative intervals longer than 12 months. Conclusion Treatment of full-thickness articular injuries of the knee in adolescent athletes with autologous chondrocyte transplantation yields a high rate of functional success at a mean follow-up of 47 months. The rate of return to demanding athletic activities is higher in cases in which the preoperative duration of symptoms is 12 months or less.

Outcomes following Microfracture of Full-Thickness Articular Cartilage Lesions of the Knee in Adolescent Patients

2014 ◽  
Vol 28 (02) ◽  
pp. 145-150 ◽  
Author(s):  
Karen Briggs ◽  
Lauren Matheny ◽  
Alyson Guillet ◽  
Chad Hanson ◽  
S. Willimon ◽  
...  
Keyword(s):  
Articular Cartilage ◽  
Full Thickness ◽  
Cartilage Lesions ◽  
Adolescent Patients ◽  
Articular Cartilage Lesions
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