Multiple primary malignancies in patients with sporadic pancreatic endocrine tumors

2008 ◽  
Vol 97 (7) ◽  
pp. 592-595 ◽  
Author(s):  
Volker Fendrich ◽  
Jens Waldmann ◽  
Detlef K. Bartsch ◽  
Katja Schlosser ◽  
Matthias Rothmund ◽  
...  
Keyword(s):  
Endocrine Tumors ◽  
Multiple Primary Malignancies ◽  
Pancreatic Endocrine Tumors ◽  
Multiple Primary

Multiple Primary Malignancies in Patients with Head and Neck Cancer

2007 ◽  
Vol 58 (2) ◽  
pp. 205-205
Author(s):  
H. Iguchi ◽  
M. Kusuki ◽  
A. Nakamura ◽  
A. Kanazawa ◽  
K. Hachiya ◽  
...  
Keyword(s):  
Head And Neck Cancer ◽  
Head And Neck ◽  
Neck Cancer ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

Nonfunctioning pancreatic endocrine tumors: a multicenter clinical study

2003 ◽  
Vol 98 (11) ◽  
pp. 2435-2439 ◽  
Author(s):  
Lucio Gullo ◽  
Marina Migliori ◽  
Massimo Falconi ◽  
Paolo Pederzoli ◽  
Rossella Bettini ◽  
...  
Keyword(s):  
Clinical Study ◽  
Endocrine Tumors ◽  
Pancreatic Endocrine Tumors ◽  
Multicenter Clinical Study

scholarly journals Pancreatic endocrine tumors

2011 ◽  
Vol 24 (S2) ◽  
pp. S66-S77 ◽  
Author(s):  
Sylvia L Asa
Keyword(s):  
Endocrine Tumors ◽  
Pancreatic Endocrine Tumors

Pancreatic Endocrine Tumors

2007 ◽  
Vol 36 (2) ◽  
pp. 431-439 ◽  
Author(s):  
Niraj Jani ◽  
A. James Moser ◽  
Asif Khalid
Keyword(s):  
Endocrine Tumors ◽  
Pancreatic Endocrine Tumors

scholarly journals Methylation-associated down-regulation of RASSF1A and up-regulation of RASSF1Cin pancreatic endocrine tumors

BMC Cancer ◽  
2011 ◽  
Vol 11 (1) ◽  
Author(s):  
Giorgio Malpeli ◽  
Eliana Amato ◽  
Mario Dandrea ◽  
Caterina Fumagalli ◽  
Valentina Debattisti ◽  
...  
Keyword(s):  
Endocrine Tumors ◽  
Down Regulation ◽  
Pancreatic Endocrine Tumors

scholarly journals Multiple primary malignancies involving lung cancer

BMC Cancer ◽  
2015 ◽  
Vol 15 (1) ◽  
Author(s):  
Feng Li ◽  
Wen-Zhao Zhong ◽  
Fei-Yu Niu ◽  
Ning Zhao ◽  
Jin-Ji Yang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Multiple Primary Malignancies ◽  
Multiple Primary

Improved histologic and clinicopathologic criteria for prognostic evaluation of pancreatic endocrine tumors

2009 ◽  
Vol 40 (1) ◽  
pp. 30-40 ◽  
Author(s):  
Stefano La Rosa ◽  
Catherine Klersy ◽  
Silvia Uccella ◽  
Linda Dainese ◽  
Luca Albarello ◽  
...  
Keyword(s):  
Endocrine Tumors ◽  
Prognostic Evaluation ◽  
Pancreatic Endocrine Tumors

Malignant pancreatic endocrine tumors

1989 ◽  
Vol 43 (4) ◽  
pp. 320-321
Author(s):  
D. Wynick
Keyword(s):  
Endocrine Tumors ◽  
Pancreatic Endocrine Tumors

scholarly journals Surgery for Gastrinoma and Insulinoma in Multiple Endocrine Neoplasia Type 1

2006 ◽  
Vol 4 (2) ◽  
pp. 148-153 ◽  
Author(s):  
Jeffrey A. Norton ◽  
Tony D. Fang ◽  
Robert T. Jensen
Keyword(s):  
Gastric Acid ◽  
Multiple Endocrine Neoplasia ◽  
Multiple Endocrine Neoplasia Type ◽  
Endocrine Tumors ◽  
Endocrine Neoplasia ◽  
Endocrine Neoplasia Type ◽  
Pancreatic Endocrine Tumors ◽  
Gastric Acid Hypersecretion ◽  
Acid Hypersecretion

The surgical management of pancreatic endocrine tumors in patients with multiple endocrine neoplasia type 1 remains controversial. Gastrinoma and insulinoma are the 2 most common functional pancreatic neuroendocrine tumors in patients with multiple endocrine neoplasia type 1. Gastrinomas cause gastric acid hypersecretion and peptic ulcer disease that are best managed using proton pump inhibitors. Surgery to remove the gastrinoma in patients with multiple endocrine neoplasia type 1 is seldom curative unless a more extensive Whipple pancreaticoduodenectomy is performed. Because the prognosis is excellent, aggressive resections such as a Whipple procedure are only indicated for large, locally metastatic, advanced tumors. Furthermore, surgery to remove imageable tumors that are 2 cm in diameter is associated with excellent outcomes and decreased probability of liver metastases. Because gastrinomas are commonly multiple and most originate in the duodenum and develop lymph node metastases, the duodenum should be opened and all tumors and lymph nodes excised. Insulinomas cause hypoglycemia that results in neuroglycopenic symptoms. Medical management of the hypoglycemia is less effective than that of the gastric acid hypersecretion. Fortunately, the insulinoma is usually clearly identified using routine pancreatic imaging studies. There is a high likelihood of cure when the insulinoma is excised surgically. However, recurrent hypoglycemia may occur, and careful follow-up is indicated.

Sign in / Sign up

Export Citation Format

Share Document