lung cancer
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2022 ◽  
Vol 12 (3) ◽  
pp. 597-601
Haibin Song ◽  
Heng Zhang ◽  
Lei Li

Deriving from bone marrow, the bone marrow mesenchymal stem cells (BMSCs) possess multipolar chemotaxis, proliferation potential, along with the capability to differentiate into various types of cells. Moreover, the hypoxic stimulation can effectively induce BMSCs differentiation. This study intends to explore the impediment of BMSCs on malignant behaviors of lung cancer stem cells under hypoxia. A co-culture system of BMSCs with A549 cells was established and then assigned into normoxia group, hypoxia group (50, 100, and 200 nmol/L) followed by analysis of cell viability by CCK-8 assay and miR-145 expression by qRT-PCR. In addition, A549 cells were grouped into NC group, miR-145-mimics group, and miR-145-inhibitors group followed by analysis of cell invasion and levels of miR-145 and Oct4. Hypoxia group exhibited a reduced cell viability and higher miR-145 expression (146.01±21.23%) compared to normoxia group (P < 0.05). Transfection of miR-145-mimic significantly upregulated miR-145 and decreased cell invasion (7.49±1.43%) compared with miR-145-inhibitors group or NC group (P < 0.05). Meanwhile, Oct4 level in miR-145-mimics group (0.934±2.98) was significantly decreased (P < 0.05). In conclusion, under hypoxia condition, the co-culture with BMSCs can upregulated miR-145 level, effectively reduce the viability of lung cancer stem cells and restrain proliferation capability.

2022 ◽  
Vol 17 (3) ◽  
pp. 931-934
Irfan Shafiq ◽  
Omar Khaled Hassan Attia Ghorab ◽  
Mohamed Abuzakouk ◽  
Samiuddin Mohammed ◽  
Mateen Haider Uzbeck ◽  

2022 ◽  
Vol 12 (4) ◽  
pp. 690-694
Wei Zhang ◽  
Yi Chen ◽  
Bin Wang ◽  
Xueren Feng ◽  
Lijuan Zhang ◽  

Lung cancer is a worldwide issue which account for the death of thousands every year. Paclitaxel (PTX) as the first line chemotherapy drug to treat lung cancer, its clinical applications is largely limited by its poor solubility. The facile preparation of pharmaceutical formulations to increase the solubility as well as targetability of PTX is of vital importance in lung cancer treatment. Herein, we introduced a facile method to prepare PTX nano-suspensions (NSs), which have high drug loading as well as well-dispersed particle size. The in vitro cell experiments revealed its capability to enhance the drug accumulation in A549 cells than free PTX. Moreover, in vivo animal assay suggested its better tumor accumulation and antitumor efficacy than PTX injection (Taxol).

2022 ◽  
Vol 76 ◽  
pp. 102079
Brendan T. Heiden ◽  
Kathryn E. Engelhardt ◽  
Chao Cao ◽  
Bryan F. Meyers ◽  
Varun Puri ◽  

2022 ◽  
Vol 112 (2) ◽  
pp. e5-e6
S.C. Lewis ◽  
A.J. Hope ◽  
M. Chan ◽  
J. Weiss ◽  
H. Raziee ◽  

2022 ◽  
Vol 146 ◽  
pp. 112500
Tae-Hee Han ◽  
Min Kyung Park ◽  
Hiroyuki Nakamura ◽  
Hyun Seung Ban

2022 ◽  
Vol 270 ◽  
pp. 271-278
Marcus Taylor ◽  
Matthew Evison ◽  
Bethan Clayton ◽  
Stuart W Grant ◽  
Glen P Martin ◽  

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