Interest of chromosomal microarray analysis in the prenatal diagnosis of fetal intrauterine growth restriction

2018 ◽  
Vol 38 (13) ◽  
pp. 1111-1119 ◽  
Author(s):  
Stephanie Brun ◽  
Perrine Pennamen ◽  
Aurelien Mattuizzi ◽  
Frederic Coatleven ◽  
Marie Laure Vuillaume ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Microarray Analysis ◽  
Intrauterine Growth Restriction ◽  
Growth Restriction ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis ◽  
Intrauterine Growth

scholarly journals The Genetic Etiology Diagnosis of Fetal Growth Restriction Using Single-Nucleotide Polymorphism-Based Chromosomal Microarray Analysis

2021 ◽  
Vol 9 ◽  
Author(s):  
Yu'e Chen ◽  
Yingjun Xie ◽  
Yuying Jiang ◽  
Qi Luo ◽  
Lijing Shi ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Microarray Analysis ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Detection Rate ◽  
Chromosomal Abnormalities ◽  
Karyotype Analysis ◽  
Growth Restriction ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis

Background: An increase in pathogenic copy number variants (pCNVs) has been recognized to associate with fetal growth restriction (FGR). Here, we aim to explore the application value of chromosomal microarray analysis (CMA) in prenatal diagnosis of FGR.Methods: Prenatal ultrasound was applied to identify FGR. A total of 149 pregnant women with FGR were enrolled in our study. All subjects underwent karyotype analysis and CMA to reveal the chromosomal abnormalities.Results: In this study, all subjects were successfully detected by karyotype and CMA analyses. Of these subjects, the chromosomal abnormalities detection rate was 5.37% (8/149) for karyotyping and 13.42% (20/149) for CMA, respectively. Among them, an 8.05% (12/149) incremental yield of CMA over karyotype analysis was observed (p = 0.004). In addition, a significant difference of pCNV detection rate was observed between the groups with different high-risk factors (p = 0.005). The FGR with structural anomalies group showed the highest pCNV detection rate (33.33%), followed by the FGR with non-structural anomalies group (8.77%) and the isolated FGR group (8.06%).Conclusion: In conclusion, CMA technology showed an effective application value in etiology diagnosis of FGR. We believe that CMA should be recommended as first-line detection technology for prenatal diagnosis in FGR.

Application of chromosomal microarray analysis in prenatal diagnosis of fetal growth restriction

2016 ◽  
Vol 36 (7) ◽  
pp. 686-692 ◽  
Author(s):  
Hui Zhu ◽  
Shaobin Lin ◽  
Linhuan Huang ◽  
Zhiming He ◽  
Xuan Huang ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Microarray Analysis ◽  
Fetal Growth ◽  
Fetal Growth Restriction ◽  
Growth Restriction ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis

Prenatal diagnosis of mosaic ring chromosome 22 associated with cardiovascular abnormalities and intrauterine growth restriction

2003 ◽  
Vol 23 (1) ◽  
pp. 40-43 ◽  
Author(s):  
Chih-Ping Chen ◽  
Schu-Rern Chern ◽  
Tung-Yao Chang ◽  
Chen-Chi Lee ◽  
Li-Feng Chen ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Intrauterine Growth Restriction ◽  
Ring Chromosome ◽  
Growth Restriction ◽  
Chromosome 22 ◽  
Intrauterine Growth ◽  
Cardiovascular Abnormalities

Chromosomal Microarray Analysis and Prenatal Diagnosis

2014 ◽  
Vol 69 (10) ◽  
pp. 613-621 ◽  
Author(s):  
Jamie O. Lo ◽  
Brian L. Shaffer ◽  
Cori D. Feist ◽  
Aaron B. Caughey
Keyword(s):  
Prenatal Diagnosis ◽  
Microarray Analysis ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis

scholarly journals Chromosomal Microarray Analysis in Fetuses with Growth Restriction and Normal Karyotype: A Systematic Review and Meta-Analysis

2017 ◽  
Vol 44 (1) ◽  
pp. 1-9 ◽  
Author(s):  
Antoni Borrell ◽  
Maribel Grande ◽  
Montse Pauta ◽  
Laia Rodriguez-Revenga ◽  
Francesc Figueras
Keyword(s):  
Systematic Review ◽  
Microarray Analysis ◽  
Meta Analysis ◽  
Normal Karyotype ◽  
Growth Restriction ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis

scholarly journals Prenatal diagnosis by chromosomal microarray analysis

2018 ◽  
Vol 109 (2) ◽  
pp. 201-212 ◽  
Author(s):  
Brynn Levy ◽  
Ronald Wapner
Keyword(s):  
Prenatal Diagnosis ◽  
Microarray Analysis ◽  
Chromosomal Microarray ◽  
Chromosomal Microarray Analysis

Microarray analysis of placental tissue in intrauterine growth restriction

2010 ◽  
Vol 72 (2) ◽  
pp. 241-247 ◽  
Author(s):  
E. Struwe ◽  
G. Berzl ◽  
R. Schild ◽  
H. Blessing ◽  
L. Drexel ◽  
...  
Keyword(s):  
Microarray Analysis ◽  
Intrauterine Growth Restriction ◽  
Placental Tissue ◽  
Growth Restriction ◽  
Intrauterine Growth

scholarly journals Prenatal diagnosis of a true umbilical cord knot in a fetus with intrauterine growth restriction and placenta accreta

2016 ◽  
Vol 55 (4) ◽  
pp. 616-617 ◽  
Author(s):  
André Campos da Cunha ◽  
Rosilene da Silveira Betat ◽  
Thaís Kappel Vieira Dal Pai ◽  
Camila Pauluci Arcolini ◽  
Amanda Muriela Gobatto ◽  
...  
Keyword(s):  
Prenatal Diagnosis ◽  
Umbilical Cord ◽  
Intrauterine Growth Restriction ◽  
Placenta Accreta ◽  
Growth Restriction ◽  
Intrauterine Growth
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