Ontogeny of epithelial modulation of airway smooth muscle function in the guinea pig

1993 ◽  
Vol 15 (2) ◽  
pp. 105-110 ◽  
Author(s):  
W. Michael Southgate ◽  
Bruce E. Pichoff ◽  
Edward L. Stevens ◽  
Venkataraman Balaraman ◽  
Catherine F. T. Uyehara ◽  
...  
1998 ◽  
Vol 31 (6) ◽  
pp. 811-818
Author(s):  
A.C. Perez ◽  
W. Paul ◽  
S. Harrison ◽  
C.P. Page ◽  
D. Spina

2000 ◽  
Vol 30 (5) ◽  
pp. 606-614 ◽  
Author(s):  
Knox ◽  
Pang ◽  
Johnson ◽  
Hamad

Author(s):  
David A. Stoltz ◽  
Michael Rector ◽  
Nick Gansemer ◽  
Lynda Ostedgaard ◽  
Qian Dong ◽  
...  

1985 ◽  
Vol 14 (2) ◽  
pp. 111-118 ◽  
Author(s):  
J.C. de Jongste ◽  
R. van Strik ◽  
I.L. Bonta ◽  
K.F. Kerrebijn

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Jingbo Zhao ◽  
Donghua Liao ◽  
Jian Yang ◽  
Hans Gregersen

This study was to generate phasic and tonic stress-strain curves for evaluation of smooth muscle function in the obstructed guinea pig jejunum. Partial and sham obstruction of the jejunum in guinea pigs was created surgically, with guinea pigs not being operated on served as normal controls. The animals survived 2, 4, 7, and 14 days, respectively. The jejunal segment was distended to 10 cm H2O. The pressure and outer diameter changes were recorded. Passive conditions were obtained by using papaverine. Total phasic, tonic, and passive circumferential stress and strain were computed from the diameter and pressure data with reference to the zero-stress-state geometry. The active phasic and tonic stresses were defined as the total phasic and tonic stress minus the passive stress. The thickness of intestinal muscle layers increased in a time-dependent manner after obstruction. The amplitude of passive, total phasic, total tonic, active phasic, and active tonic circumferential stresses increased as function of strain 7 days after obstruction. However, when normalized to muscle layer thickness, the amplitude of active stresses did not differ among the groups. In conclusion, the long-term-obstructed intestine exhibits increased total smooth muscle contraction force. However, the contraction force per smooth muscle unit did not increase.


1987 ◽  
Vol 136 (4_pt_2) ◽  
pp. S50-S54 ◽  
Author(s):  
James B. A. Palmer ◽  
Peter J. Barnes

2014 ◽  
pp. 730-738
Author(s):  
Andrew J. Halayko ◽  
Thai Tran

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