scholarly journals KV7 Channel Pharmacological Activation by the Novel Activator ML213: Role for Heteromeric KV7.4/KV7.5 Channels in Guinea Pig Detrusor Smooth Muscle Function

2017 ◽  
Vol 364 (1) ◽  
pp. 131-144 ◽  
Author(s):  
Aaron Provence ◽  
Damiano Angoli ◽  
Georgi V. Petkov
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Muscle Function ◽  
Detrusor Smooth Muscle ◽  
The Novel ◽  
Smooth Muscle Function

scholarly journals Bladder instability and detrusor smooth muscle function

1999 ◽  
Vol 84 (1) ◽  
pp. 161-169 ◽  
Author(s):  
C. H. Fry ◽  
C. Wu ◽  
A. R. Mundy
Keyword(s):  
Smooth Muscle ◽  
Muscle Function ◽  
Detrusor Smooth Muscle ◽  
Smooth Muscle Function

scholarly journals Phasic and Tonic Smooth Muscle Function of the Partially Obstructed Guinea Pig Intestine

2011 ◽  
Vol 2011 ◽  
pp. 1-9 ◽  
Author(s):  
Jingbo Zhao ◽  
Donghua Liao ◽  
Jian Yang ◽  
Hans Gregersen
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Guinea Pigs ◽  
Muscle Function ◽  
Circumferential Stress ◽  
Outer Diameter ◽  
Dependent Manner ◽  
Contraction Force ◽  
Jejunal Segment ◽  
Smooth Muscle Function

This study was to generate phasic and tonic stress-strain curves for evaluation of smooth muscle function in the obstructed guinea pig jejunum. Partial and sham obstruction of the jejunum in guinea pigs was created surgically, with guinea pigs not being operated on served as normal controls. The animals survived 2, 4, 7, and 14 days, respectively. The jejunal segment was distended to 10 cm H2O. The pressure and outer diameter changes were recorded. Passive conditions were obtained by using papaverine. Total phasic, tonic, and passive circumferential stress and strain were computed from the diameter and pressure data with reference to the zero-stress-state geometry. The active phasic and tonic stresses were defined as the total phasic and tonic stress minus the passive stress. The thickness of intestinal muscle layers increased in a time-dependent manner after obstruction. The amplitude of passive, total phasic, total tonic, active phasic, and active tonic circumferential stresses increased as function of strain 7 days after obstruction. However, when normalized to muscle layer thickness, the amplitude of active stresses did not differ among the groups. In conclusion, the long-term-obstructed intestine exhibits increased total smooth muscle contraction force. However, the contraction force per smooth muscle unit did not increase.

Ontogeny of epithelial modulation of airway smooth muscle function in the guinea pig

1993 ◽  
Vol 15 (2) ◽  
pp. 105-110 ◽  
Author(s):  
W. Michael Southgate ◽  
Bruce E. Pichoff ◽  
Edward L. Stevens ◽  
Venkataraman Balaraman ◽  
Catherine F. T. Uyehara ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Airway Smooth Muscle ◽  
Muscle Function ◽  
Smooth Muscle Function

In vivo and in vitro effects of the novel antiarrhythmic ipazilide on cardiac and vascular smooth muscle function

1992 ◽  
Vol 27 (2) ◽  
pp. 107-120
Author(s):  
Alan M. Ezrin ◽  
King C. Lee ◽  
Alex L. Harris ◽  
Paul J. Silver
Keyword(s):  
Smooth Muscle ◽  
Vascular Smooth Muscle ◽  
Muscle Function ◽  
The Novel ◽  
Smooth Muscle Function ◽  
In Vitro Effects

scholarly journals The effect of L-arginine on guinea-pig and rabbit airway smooth muscle function in vitro

1998 ◽  
Vol 31 (6) ◽  
pp. 811-818
Author(s):  
A.C. Perez ◽  
W. Paul ◽  
S. Harrison ◽  
C.P. Page ◽  
D. Spina
Keyword(s):  
Smooth Muscle ◽  
Guinea Pig ◽  
Airway Smooth Muscle ◽  
Muscle Function ◽  
Smooth Muscle Function
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