scholarly journals Fisher information matrix for nonlinear mixed effects multiple response models: Evaluation of the appropriateness of the first order linearization using a pharmacokinetic/pharmacodynamic model

2009 ◽  
Vol 28 (14) ◽  
pp. 1940-1956 ◽  
Author(s):  
Caroline Bazzoli ◽  
Sylvie Retout ◽  
France Mentré
Keyword(s):  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Mixed Effects ◽  
Pharmacodynamic Model ◽  
Multiple Response ◽  
Nonlinear Mixed Effects ◽  
Response Models ◽  
First Order

scholarly journals Optimal design for population pk/pd models

2012 ◽  
Vol 51 (1) ◽  
pp. 115-130
Author(s):  
Sergei Leonov ◽  
Alexander Aliev
Keyword(s):  
Optimal Design ◽  
Fisher Information ◽  
Fisher Information Matrix ◽  
Information Matrix ◽  
Optimal Sampling ◽  
Design Algorithm ◽  
Sampling Schemes ◽  
Population Pk ◽  
Different Types

ABSTRACT We provide some details of the implementation of optimal design algorithm in the PkStaMp library which is intended for constructing optimal sampling schemes for pharmacokinetic (PK) and pharmacodynamic (PD) studies. We discuss different types of approximation of individual Fisher information matrix and describe a user-defined option of the library.

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