Comments on “Adaptive sample size modification in clinical trials: Start small then ask for more?”

2019 ◽  
Vol 39 (1) ◽  
pp. 97-98
Author(s):  
Maximilian Pilz ◽  
Meinhard Kieser ◽  
Kevin Kunzmann
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Size Modification

Practical midcourse sample size modification in clinical trials

2003 ◽  
Vol 24 (1) ◽  
pp. 4-15 ◽  
Author(s):  
Michael A. Proschan ◽  
Qing Liu ◽  
Sally Hunsberger
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Size Modification

Mid-course sample size modification in clinical trials based on the observed treatment effect

2003 ◽  
Vol 22 (6) ◽  
pp. 971-993 ◽  
Author(s):  
Christopher Jennison ◽  
Bruce W. Turnbull
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Treatment Effect ◽  
Size Modification

scholarly journals Adaptive sample size modification in clinical trials: start small then ask for more?

2015 ◽  
Vol 34 (29) ◽  
pp. 3793-3810 ◽  
Author(s):  
Christopher Jennison ◽  
Bruce W. Turnbull
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Size Modification

Planning the Size of Clinical Trials with Allowance for Patient Noncompliance

1990 ◽  
Vol 29 (03) ◽  
pp. 243-246 ◽  
Author(s):  
M. A. A. Moussa
Keyword(s):  
Clinical Trial ◽  
Clinical Trials ◽  
Sample Size ◽  
Event Rate ◽  
Survival Functions ◽  
Time Intervals ◽  
Patient Noncompliance ◽  
Event Rates ◽  
Larger Sample

AbstractVarious approaches are considered for adjustment of clinical trial size for patient noncompliance. Such approaches either model the effect of noncompliance through comparison of two survival distributions or two simple proportions. Models that allow for variation of noncompliance and event rates between time intervals are also considered. The approach that models the noncompliance adjustment on the basis of survival functions is conservative and hence requires larger sample size. The model to be selected for noncompliance adjustment depends upon available estimates of noncompliance and event rate patterns.

scholarly journals Do patient characteristics matter when calculating sample size for eczema clinical trials?

2021 ◽  
Author(s):  
L. Howells ◽  
S. Gran ◽  
J. R. Chalmers ◽  
B. Stuart ◽  
M. Santer ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Patient Characteristics

Sample size calculation for clinical trials in which entry criteria and outcomes are counts of events

1994 ◽  
Vol 13 (8) ◽  
pp. 859-870 ◽  
Author(s):  
Robert P. McMahon ◽  
Michael Proschan ◽  
Nancy L. Geller ◽  
Peter H. Stone ◽  
George Sopko
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Sample Size Calculation

scholarly journals Diffuse myocardial fibrosis evaluation using cardiac magnetic resonance T1 mapping: sample size considerations for clinical trials

2012 ◽  
Vol 14 (1) ◽  
pp. 90 ◽  
Author(s):  
Songtao Liu ◽  
Jing Han ◽  
Marcelo S Nacif ◽  
Jacquin Jones ◽  
Nadine Kawel ◽  
...  
Keyword(s):  
Clinical Trials ◽  
Cardiac Magnetic Resonance ◽  
Magnetic Resonance ◽  
Sample Size ◽  
Myocardial Fibrosis ◽  
T1 Mapping ◽  
Diffuse Myocardial Fibrosis

scholarly journals Maximum type 1 error rate inflation in multiarmed clinical trials with adaptive interim sample size modifications

2014 ◽  
Vol 56 (4) ◽  
pp. 614-630 ◽  
Author(s):  
Alexandra C. Graf ◽  
Peter Bauer ◽  
Ekkehard Glimm ◽  
Franz Koenig
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Error Rate ◽  
Type 1 Error ◽  
Multiarmed Clinical Trials

Sample size re-estimation in group-sequential response-adaptive clinical trials

2003 ◽  
Vol 22 (24) ◽  
pp. 3843-3857 ◽  
Author(s):  
Caroline C. Morgan
Keyword(s):  
Clinical Trials ◽  
Sample Size ◽  
Group Sequential ◽  
Adaptive Clinical Trials
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