A strategy for the palladium-catalyzed dehydrative tandem benzylation of 2-morpholinoanilines with benzyl alcohols has been developed. This cascade reaction is devised as a straightforward and efficient synthetic route for N-(1,2-diphenylethyl)-2-morpholinoanilines.
Palladium catalyzed direct and regioselective cross dehydrogenative coupling (CDC) of 2-arylquinazoline-4-one endowed with a quinazolinone nucleus as an inherent directing group with aldehyde and oxidative coupling with benzyl alcohol was developed.
