selective acylation
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2022 ◽  
Vol 18 ◽  
pp. 89-94
Author(s):  
Tianri Du ◽  
Xiangmu Wei ◽  
Honghong Xu ◽  
Xin Zhang ◽  
Ruiru Fang ◽  
...  

The selective acylation of indoles often requires sensitive and reactive acyl chloride derivatives. Here, we report a mild, efficient, functional group tolerant, and highly chemoselective N-acylation of indoles using thioesters as a stable acyl source. A series of indoleamides have been obtained with moderate to good yields. In addition, heterocycles, such as carbazole, can also be used as nucleophiles in this reaction.


Author(s):  
Amarendra Mohan Khan ◽  
Narinder Kumar Agnihotri ◽  
Vinay Kumar Singh ◽  
Subash Chandra Mohapatra ◽  
Divya Mathur ◽  
...  

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
Qing-Yuan Meng ◽  
Lena Lezius ◽  
Armido Studer

AbstractMethods that enable site selective acylation of sp3 C-H bonds in complex organic molecules are not well explored, particularly if compared with analogous transformations of aromatic and vinylic sp2 C-H bonds. We report herein a direct acylation of benzylic C-H bonds by merging N-heterocyclic carbene (NHC) and photoredox catalysis. The method allows the preparation of a diverse range of benzylic ketones with good functional group tolerance under mild conditions. The reaction can be used to install acyl groups on highly functionalized natural product derived compounds and the C-H functionalization works with excellent site selectivity. The combination of NHC and photoredox catalysis offers options in preparing benzyl aryl ketones.


2021 ◽  
Vol 86 (5) ◽  
pp. 3907-3922
Author(s):  
Alexander Seitz ◽  
Raffael C. Wende ◽  
Emily Roesner ◽  
Dominik Niedek ◽  
Christopher Topp ◽  
...  

2020 ◽  
Vol 142 (51) ◽  
pp. 21237-21242
Author(s):  
Heemal H. Dhanjee ◽  
Ivan Buslov ◽  
Ian W. Windsor ◽  
Ronald T. Raines ◽  
Bradley L. Pentelute ◽  
...  

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