Reaction Optimization: A High-Throughput Experimentation Approach

2021 ◽  
pp. 527-552
Author(s):  
Simon Berritt ◽  
Jason R. Schmink ◽  
Ana Inés Bellomo Peraza
Keyword(s):  
High Throughput ◽  
Reaction Optimization ◽  
High Throughput Experimentation

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

2021 ◽  
Author(s):  
Jonas Rein ◽  
James R. Annand ◽  
Michael K. Wismer ◽  
Jiantao Fu ◽  
Juno C. Siu ◽  
...  
Keyword(s):  
High Throughput ◽  
Electrochemical Reaction ◽  
Electrochemical Reactor ◽  
Constant Current ◽  
Library Synthesis ◽  
Chemical Library ◽  
Reaction Discovery ◽  
Reaction Optimization ◽  
High Throughput Experimentation ◽  
Broad Array

Organic electrochemistry has emerged as an enabling and sustainable technology in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochemistry in the synthetic community and, especially in industrial settings, has been hindered by the dearth of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HT<i>e<sup>-</sup></i>Chem, a high-throughput microscale electrochemical reactor that is compatible with existing HTE infrastructure, and enables rapid evaluation of a broad array of electrochemical reaction parameters. Utilizing the HT<i>e<sup>-</sup></i>Chem to accelerate reaction optimization, reaction discovery, and chemical library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochemical conditions.

scholarly journals Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

2021 ◽  
Author(s):  
Jonas Rein ◽  
James R. Annand ◽  
Michael K. Wismer ◽  
Jiantao Fu ◽  
Juno C. Siu ◽  
...  
Keyword(s):  
High Throughput ◽  
Electrochemical Reaction ◽  
Electrochemical Reactor ◽  
Constant Current ◽  
Library Synthesis ◽  
Chemical Library ◽  
Reaction Discovery ◽  
Reaction Optimization ◽  
High Throughput Experimentation ◽  
Broad Array

Organic electrochemistry has emerged as an enabling and sustainable technology in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochemistry in the synthetic community and, especially in industrial settings, has been hindered by the dearth of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HT<i>e<sup>-</sup></i>Chem, a high-throughput microscale electrochemical reactor that is compatible with existing HTE infrastructure, and enables rapid evaluation of a broad array of electrochemical reaction parameters. Utilizing the HT<i>e<sup>-</sup></i>Chem to accelerate reaction optimization, reaction discovery, and chemical library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochemical conditions.

Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

2021 ◽  
Author(s):  
Jonas Rein ◽  
James R. Annand ◽  
Michael K. Wismer ◽  
Jiantao Fu ◽  
Juno C. Siu ◽  
...  
Keyword(s):  
High Throughput ◽  
Electrochemical Reaction ◽  
Electrochemical Reactor ◽  
Constant Current ◽  
Library Synthesis ◽  
Chemical Library ◽  
Reaction Discovery ◽  
Reaction Optimization ◽  
High Throughput Experimentation ◽  
Broad Array

Organic electrochemistry has emerged as an enabling and sustainable technology in modern organic synthesis. Despite the recent renaissance of electrosynthesis, the broad adoption of electrochemistry in the synthetic community and, especially in industrial settings, has been hindered by the dearth of general, standardized platforms for high-throughput experimentation (HTE). Herein, we disclose the design of the HT<i>e<sup>-</sup></i>Chem, a high-throughput microscale electrochemical reactor that is compatible with existing HTE infrastructure, and enables rapid evaluation of a broad array of electrochemical reaction parameters. Utilizing the HT<i>e<sup>-</sup></i>Chem to accelerate reaction optimization, reaction discovery, and chemical library synthesis is illustrated using a suite of oxidative and reductive transformations under constant current, constant voltage, and electrophotochemical conditions.

scholarly journals Titanium Complexes with Functional Alkoxido Ligands for Selective Ethylene Dimerization – A High Throughput Experimentation Approach

ChemCatChem ◽  
2021 ◽  
Author(s):  
Fabien L. Grasset ◽  
Richard Welter ◽  
Pierre Braunstein ◽  
Hélène Olivier‐Bourbigou ◽  
Lionel Magna
Keyword(s):  
High Throughput ◽  
Titanium Complexes ◽  
Ethylene Dimerization ◽  
High Throughput Experimentation

scholarly journals Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor

2021 ◽  
Author(s):  
Jonas Rein ◽  
James R. Annand ◽  
Michael K. Wismer ◽  
Jiantao Fu ◽  
Juno C. Siu ◽  
...  
Keyword(s):  
High Throughput ◽  
High Throughput Experimentation

ChemInform Abstract: High Throughput Experimentation for the Synthesis of New Crystalline Microporous Solids.

ChemInform ◽  
2010 ◽  
Vol 33 (13) ◽  
pp. no-no
Author(s):  
John M. Newsam ◽  
Thomas Bein ◽  
Jens Klein ◽  
Wilhelm F. Maier ◽  
Wolfram Stichert
Keyword(s):  
High Throughput ◽  
High Throughput Experimentation ◽  
Microporous Solids

High throughput experimentation in oxidation catalysis: Higher integration and “intelligent” software

2006 ◽  
Vol 117 (1-3) ◽  
pp. 284-290 ◽  
Author(s):  
F SCHUTH ◽  
L BAUMES ◽  
F CLERC ◽  
D DEMUTH ◽  
D FARRUSSENG ◽  
...  
Keyword(s):  
High Throughput ◽  
Oxidation Catalysis ◽  
Intelligent Software ◽  
High Throughput Experimentation

Catalyst design: knowledge extraction from high-throughput experimentation

2003 ◽  
Vol 216 (1-2) ◽  
pp. 98-109 ◽  
Author(s):  
J.M. Caruthers ◽  
J.A. Lauterbach ◽  
K.T. Thomson ◽  
V. Venkatasubramanian ◽  
C.M. Snively ◽  
...  
Keyword(s):  
High Throughput ◽  
Knowledge Extraction ◽  
Catalyst Design ◽  
Design Knowledge ◽  
High Throughput Experimentation
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