Organic
electrochemistry has emerged as an enabling and sustainable technology in
modern organic synthesis. Despite the recent renaissance of electrosynthesis,
the broad adoption of electrochemistry in the synthetic community and,
especially in industrial settings, has been hindered by the dearth of general,
standardized platforms for high-throughput experimentation (HTE). Herein, we
disclose the design of the HT<i>e<sup>-</sup></i>Chem,
a high-throughput microscale electrochemical reactor that is compatible with
existing HTE infrastructure, and enables rapid evaluation of a broad array of electrochemical
reaction parameters. Utilizing the HT<i>e<sup>-</sup></i>Chem
to accelerate reaction optimization, reaction discovery, and chemical library
synthesis is illustrated using a suite of oxidative and reductive transformations
under constant current, constant voltage, and electrophotochemical conditions.
Unlocking the Potential of High-Throughput Experimentation for Electrochemistry with a Standardized Microscale Reactor