MAP Kinase Kinase Kinase Kinase (MAPKKKK)

2008 ◽  
pp. 1151-1151
Keyword(s):  
Map Kinase ◽  
Map Kinase Kinase Kinase ◽  
Map Kinase Kinase

scholarly journals CZK3, a MAP Kinase Kinase Kinase Homolog in Cercospora zeae-maydis, Regulates Cercosporin Biosynthesis, Fungal Development, and Pathogenesis

2003 ◽  
Vol 16 (9) ◽  
pp. 760-768 ◽  
Author(s):  
Won-Bo Shim ◽  
Larry D. Dunkle
Keyword(s):  
Map Kinase ◽  
Map Kinases ◽  
Gray Leaf Spot ◽  
Open Reading Frame ◽  
Wild Type ◽  
Toxic Activity ◽  
Reading Frame ◽  
Cercospora Zeae Maydis ◽  
Map Kinase Kinase Kinase ◽  
Map Kinase Kinase

The fungus Cercospora zeae-maydis causes gray leaf spot of maize and produces cercosporin, a photosensitizing perylenequinone with toxic activity against a broad spectrum of organisms. However, little is known about the biosynthetic pathway or factors that regulate cercosporin production. Analysis of a cDNA subtraction library comprised of genes that are up-regulated during cercosporin synthesis revealed a sequence highly similar to mitogen-activated protein (MAP) kinases in other fungi. Sequencing and conceptual translation of the full-length genomic sequence indicated that the gene, which we designated CZK3, contains a 4,119-bp open reading frame devoid of introns and encodes a 1,373-amino acid sequence that is highly similar to Wis4, a MAP kinase kinase kinase in Schizosaccharomyces pombe. Targeted disruption of CZK3 suppressed expression of genes predicted to participate in cercosporin biosynthesis and abolished cercosporin production. The disrupted mutants grew faster on agar media than the wild type but were deficient in conidiation and elicited only small chlorotic spots on inoculated maize leaves compared with rectangular necrotic lesions incited by the wild type. Complementation of disruptants with the CZK3 open reading frame and flanking sequences restored wild-type levels of conidiation, growth rate, and virulence as well as the ability to produce cercosporin. The results suggest that cercosporin is a virulence factor in C. zeae-maydis during maize pathogenesis, but the pleiotropic effects of CZK3 disruption precluded definitive conclusions.

scholarly journals Silencing PsKPP4 , a MAP kinase kinase kinase gene, reduces pathogenicity of the stripe rust fungus

2018 ◽  
Vol 19 (12) ◽  
pp. 2590-2602 ◽  
Author(s):  
Xiaoguo Zhu ◽  
Jia Guo ◽  
Fuxin He ◽  
Yang Zhang ◽  
Chenglong Tan ◽  
...  
Keyword(s):  
Map Kinase ◽  
Stripe Rust ◽  
Rust Fungus ◽  
Kinase Gene ◽  
Stripe Rust Fungus ◽  
Map Kinase Kinase Kinase ◽  
Map Kinase Kinase

The ScFRK2 MAP kinase kinase kinase from Solanum chacoense affects pollen development and viability

Planta ◽  
2006 ◽  
Vol 225 (5) ◽  
pp. 1221-1231 ◽  
Author(s):  
Martin O’Brien ◽  
Madoka Gray-Mitsumune ◽  
Christelle Kapfer ◽  
Charles Bertrand ◽  
Daniel P. Matton
Keyword(s):  
Map Kinase ◽  
Pollen Development ◽  
Solanum Chacoense ◽  
Map Kinase Kinase Kinase ◽  
Map Kinase Kinase

Activation of MEK-1 and SEK-1 by Tpl-2 proto-oncoprotein, a novel MAP kinase kinase kinase.

1996 ◽  
Vol 15 (4) ◽  
pp. 817-826 ◽  
Author(s):  
A. Salmeron ◽  
T. B. Ahmad ◽  
G. W. Carlile ◽  
D. Pappin ◽  
R. P. Narsimhan ◽  
...  
Keyword(s):  
Map Kinase ◽  
Map Kinase Kinase Kinase ◽  
Map Kinase Kinase

scholarly journals Attenuation of pattern recognition receptor signaling is mediated by a MAP kinase kinase kinase

EMBO Reports ◽  
2016 ◽  
Vol 17 (3) ◽  
pp. 441-454 ◽  
Author(s):  
Sharon C Mithoe ◽  
Christina Ludwig ◽  
Michiel JC Pel ◽  
Mara Cucinotta ◽  
Alberto Casartelli ◽  
...  
Keyword(s):  
Pattern Recognition ◽  
Map Kinase ◽  
Pattern Recognition Receptor ◽  
Receptor Signaling ◽  
Recognition Receptor ◽  
Map Kinase Kinase Kinase ◽  
Map Kinase Kinase
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