Inhibitor Binding to Thymidylate Synthase Is Mediated by Different Structural Determinants than Those That Promote Tight Binding to Dihydrofolate Reductase

1990 ◽  
pp. 1-8 ◽  
Author(s):  
David A. Matthews ◽  
Cheryl A. Janson ◽  
Ward W. Smith
Keyword(s):  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Tight Binding ◽  
Structural Determinants ◽  
Inhibitor Binding

Conformationally restricted analogues designed for selective inhibition of GAR Tfase versus thymidylate synthase or dihydrofolate reductase

2000 ◽  
Vol 8 (5) ◽  
pp. 1075-1086 ◽  
Author(s):  
Dale L. Boger ◽  
Marc A. Labroli ◽  
Thomas H. Marsilje ◽  
Qing Jin ◽  
Michael P. Hedrick ◽  
...  
Keyword(s):  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Selective Inhibition ◽  
Conformationally Restricted ◽  
Gar Tfase

Analysis of the Plasmodium vivax dihydrofolate reductase–thymidylate synthase gene sequence

Gene ◽  
1998 ◽  
Vol 211 (1) ◽  
pp. 177-185 ◽  
Author(s):  
Philippe Eldin de Pécoulas ◽  
Leonardo K Basco ◽  
Rachida Tahar ◽  
Taoufik Ouatas ◽  
André Mazabraud
Keyword(s):  
Plasmodium Vivax ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Gene Sequence

Malarial (Plasmodium falciparum) dihydrofolate reductase-thymidylate synthase: structural basis for antifolate resistance and development of effective inhibitors

Parasitology ◽  
2005 ◽  
Vol 130 (3) ◽  
pp. 249-259 ◽  
Author(s):  
Y. YUTHAVONG ◽  
J. YUVANIYAMA ◽  
P. CHITNUMSUB ◽  
J. VANICHTANANKUL ◽  
S. CHUSACULTANACHAI ◽  
...  
Keyword(s):  
Plasmodium Falciparum ◽  
Dihydrofolate Reductase ◽  
Thymidylate Synthase ◽  
Structural Basis ◽  
Antifolate Resistance
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