Relation of Brain Serotonin to the Inhibition and Enhancement of Morphine Tolerance and Physical Dependence

1973 ◽  
pp. 279-295 ◽  
Author(s):  
E. Leong Way ◽  
Ing K. Ho ◽  
Horace H. Lob
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance ◽  
Brain Serotonin

scholarly journals The Role of CGRP in the Development of Morphine Tolerance and Physical Dependence

2001 ◽  
Vol 1 ◽  
pp. 21-21
Author(s):  
K. J. Powell ◽  
T. Trang ◽  
R. Quirion ◽  
K. Jhamandas
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

Effects of naltrexone pellet implantation on morphine tolerance and physical dependence in the rat

1994 ◽  
Vol 25 (1) ◽  
pp. 149-155 ◽  
Author(s):  
Hemendra N. Bhargava ◽  
George A. Matwyshyn ◽  
Phillip M. Gerk ◽  
Pamela S. Bozek ◽  
Melissa D. Bailey ◽  
...  
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

scholarly journals Honey potentially mitigates morphine analgesic tolerance and physical dependence in rats

2018 ◽  
Vol 17 (1) ◽  
pp. 138-143
Author(s):  
Siti Norhajah Hashim ◽  
Nasir Mohamad ◽  
Zulkifli Mustapha ◽  
Nor Hidayah Abu Bakar ◽  
Rohayah Husain ◽  
...  
Keyword(s):  
Analgesic Effect ◽  
Physical Dependence ◽  
Medical Science ◽  
Morphine Tolerance ◽  
Morphine Dependence ◽  
P Value ◽  
Concomitant Treatment ◽  
Sprague Dawley ◽  
Chronic Morphine ◽  
Analgesic Tolerance

Introduction:Honey has been used traditionally in medicine as well as food supplements. Honeybees are said to be able to cure many diseases. However, its influences on opioid tolerance and dependence have not yet been clarified.Materials and Methods:Adult male Sprague- Dawley rats were rendered tolerant to the analgesic effect of morphine by injection of morphine (10 mg/kg, i.p.) twice daily for 14 days. To develop morphine dependence rats given escalating doses of chronic morphine. To determine the effect of stingless bee honey on the development of morphine tolerance and dependence. The hotplate and naloxone precipitation tests were used to assess the degree of tolerance and dependence, respectively.The results: Our results showed that chronic morphine-injected rats displayed tolerance to the analgesic effect of morphine as well as morphine dependence. Methadone+morphine (MetM), methadone+morphine+ honey (MetMH) and morphine+Honey (MH) significantlylower the development of morphine tolerance with p-value p<0.05. In addition, concomitant treatment of morphine with MH and MetMH attenuated almost all of the naloxone-induced withdrawal signs which include abdominal contraction, diarrhea, pertussis, teeth chattering, and jumping.Conclusion: The data indicate that honey has a potential to reduce tolerant and dependence property.Bangladesh Journal of Medical Science Vol.17(1) 2018 p.138-143

The role of vasopressin on the effect of U-50,488 to block the development of morphine tolerance and physical dependence

1997 ◽  
Vol 355 (2) ◽  
pp. 281-287 ◽  
Author(s):  
P.-L. Tao ◽  
Wan-Cherng Liu ◽  
Yuan-Sheng Tsuei ◽  
Chen-Yu Cheng
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance

The Role of Hydrogen Sulfide in the Development of Tolerance and Dependence to Morphine in Mice

2020 ◽  
pp. 1-7
Author(s):  
Zeynep Cetin ◽  
Ozgur Gunduz ◽  
Ruhan D. Topuz ◽  
Dikmen Dokmeci ◽  
Hakan C. Karadag ◽  
...  
Keyword(s):  
Hydrogen Sulfide ◽  
Physical Dependence ◽  
Morphine Tolerance ◽  
Morphine Dependence ◽  
Tail Flick ◽  
Pain Mechanisms ◽  
Antinociceptive Effects ◽  
Synthase Inhibitor ◽  
Development Of Tolerance

<b><i>Objective:</i></b> Hydrogen sulfide is an endogenous gaseous mediator that has been indicated to have a role in pain mechanisms. In this study, we aimed to detect brain and spinal cord hydrogen sulfide levels during different phases of tolerance and dependence to morphine and to determine the effects of inhibition of endogenous hydrogen sulfide production on the development of tolerance and dependence. <b><i>Methods:</i></b> Morphine tolerance and dependence was developed by subcutaneous injection of morphine (10 mg/kg) twice daily for 12 days. Physical dependence was determined by counting the jumps for 20 min, which is a withdrawal symptom occurring after a single dose of naloxone (5 mg/kg) administered intraperitoneally (i.p.). Propargylglycine (30 mg/kg, i.p.), a cystathionine-γ-lyase inhibitor, and hydroxylamine (12.5 mg/kg, i.p.), a cystathionine-β-synthase inhibitor, were used as hydrogen sulfide synthase inhibitors. The tail-flick and hot-plate tests were used to determine the loss of antinociceptive effects of morphine and development of tolerance. <b><i>Results:</i></b> It was found that chronic and acute uses of both propargylglycine and hydroxylamine prevented the development of tolerance to morphine, whereas they had no effect on morphine dependence. Chronic and acute administrations of hydrogen sulfide synthase inhibitors did not exert any difference in hydrogen sulfide levels in brain and spinal cords of both morphine-tolerant and -dependent animals. <b><i>Conclusion:</i></b> It has been concluded that hydrogen sulfide synthase inhibitors may have utility in preventing morphine tolerance.

scholarly journals ACUTE MORPHINE TOLERANCE AND PHYSICAL DEPENDENCE IN RATS

1973 ◽  
Vol 23 ◽  
pp. 57
Author(s):  
Hiroyuki Yamamoto ◽  
Ichiro Yano ◽  
Tadashi Murano
Keyword(s):  
Physical Dependence ◽  
Morphine Tolerance
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